Genetics, epigenetics and transgenerational transmission of obesity in children

N Panera, C Mandato, A Crudele… - Frontiers in …, 2022 - frontiersin.org
Sedentary lifestyle and consumption of high-calorie foods have caused a relentless increase
of overweight and obesity prevalence at all ages. Its presently epidemic proportion is …

The genetics of obesity: FTO leads the way

KA Fawcett, I Barroso - Trends in genetics, 2010 - cell.com
In 2007, an association of single nucleotide polymorphisms (SNPs) in the fat mass and
obesity-associated (FTO) gene region with body mass index (BMI) and risk of obesity was …

FTO gene polymorphisms and obesity risk: a meta-analysis

S Peng, Y Zhu, F Xu, X Ren, X Li, M Lai - BMC medicine, 2011 - Springer
Background The pathogenesis of obesity is reportedly related to variations in the fat mass
and an obesity-associated gene (FTO); however, as the number of reports increases …

Gender in childhood obesity: family environment, hormones, and genes

AB Wisniewski, SD Chernausek - Gender medicine, 2009 - Elsevier
Background: The prevalence of obesity among children in the United States represents a
pool of latent morbidity. Though the prevalence of obesity has increased in both boys and …

The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels

T Berulava, B Horsthemke - European Journal of Human Genetics, 2010 - nature.com
As shown by genome-wide association studies single-nucleotide polymorphisms (SNPs)
within intron 1 of the FTO gene are associated with the body mass index and type II …

[HTML][HTML] Genome wide analysis reveals association of a FTO gene variant with epigenetic changes

MS Almén, JA Jacobsson, G Moschonis, C Benedict… - Genomics, 2012 - Elsevier
Variants of the FTO gene show strong association with obesity, but the mechanisms behind
this association remain unclear. We determined the genome wide DNA methylation profile in …

Increasing heritability of BMI and stronger associations with the FTO gene over childhood

CMA Haworth, S Carnell, EL Meaburn, OSP Davis… - …, 2008 - Wiley Online Library
The growing evidence of health risks associated with the rise in childhood obesity adds to
the urgency of understanding the determinants of BMI. Twin analyses on repeated …

Polymorphisms of fat mass and obesity-associated gene in the pathogenesis of child and adolescent metabolic syndrome

Y Song, H Wade, B Zhang, W Xu, R Wu, S Li, Q Su - Nutrients, 2023 - mdpi.com
Childhood metabolic syndrome (MetS) is prevalent around the world and is associated with
a high likelihood of suffering from severe diseases such as cardiovascular disease later in …

Genome-wide association study of circulating retinol levels

AM Mondul, K Yu, W Wheeler, H Zhang… - Human molecular …, 2011 - academic.oup.com
Retinol is one of the most biologically active forms of vitamin A and is hypothesized to
influence a wide range of human diseases including asthma, cardiovascular disease …

FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity

M Hakanen, OT Raitakari, T Lehtimaki… - The Journal of …, 2009 - academic.oup.com
Context: A common variant in the FTO gene, rs9939609, associates with body mass index
(BMI) in adults and in children aged 7 yr or older. Objective: Our aim was to examine the …