Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the
neuronal compartment, but includes strong interactions with immunological mechanisms in …

Globally, there is a huge unmet need for effective treatments for neurodegenerative
diseases. The complexity of the molecular mechanisms underlying neuronal degeneration …

Communication within the glial cell ecosystem is essential for neuronal and brain health,–.
The influence of glial cells on the accumulation and clearance of β-amyloid (Aβ) and …

The pathway leading from amyloid-β deposition to cognitive impairment is believed to be a
cornerstone of the pathogenesis of Alzheimer's disease (AD). However, what drives amyloid …

Alzheimer's disease (AD) is a complex, heterogeneous, progressive disease and is the most
common type of neurodegenerative dementia. The prevalence of AD is expected to increase …

Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly
characterized from an integrative perspective. Here spatiotemporal alterations in brain …

Alzheimer's disease constitutes a rising threat to public health. Despite extensive research in
cellular and animal models, identifying the pathogenic agent present in the human brain and …

'Inflammaging'refers to the chronic, low-grade inflammation that characterizes aging.
Inflammaging is macrophage centered, involves several tissues and organs, including the …

Although systemic diseases take the biggest toll on human health and well-being,
increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the …

Alzheimer's disease (AD) is a devastating age-related neurodegenerative disorder with an
alarming increasing prevalence. Except for the recently FDA-approved Aducanumab of …