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The challenge of antimicrobial resistance: what economics can contribute
BACKGROUND Antimicrobial resistance (AMR) is increasing, driven by widespread
antibiotic use. The wide availability of effective antibiotics is under threat, jeopardizing …
antibiotic use. The wide availability of effective antibiotics is under threat, jeopardizing …
Evolutionary mechanisms sha** the maintenance of antibiotic resistance
Antibiotics target essential cellular functions but bacteria can become resistant by acquiring
either exogenous resistance genes or chromosomal mutations. Resistance mutations …
either exogenous resistance genes or chromosomal mutations. Resistance mutations …
Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms
MCR-1 is a lipid A modifying enzyme that confers resistance to the antibiotic colistin. Here,
we analyse the impact of MCR-1 expression on E. coli morphology, fitness, competitiveness …
we analyse the impact of MCR-1 expression on E. coli morphology, fitness, competitiveness …
Regulatory fine-tuning of mcr-1 increases bacterial fitness and stabilises antibiotic resistance in agricultural settings
Antibiotic resistance tends to carry fitness costs, making it difficult to understand how
resistance can be maintained in the absence of continual antibiotic exposure. Here we …
resistance can be maintained in the absence of continual antibiotic exposure. Here we …
Insights into the resistome of bovine clinical mastitis microbiome, a key factor in disease complication
Bovine clinical mastitis (CM) is one of the most prevalent diseases caused by a wide range
of resident microbes. The emergence of antimicrobial resistance in CM bacteria is well …
of resident microbes. The emergence of antimicrobial resistance in CM bacteria is well …
Epistasis and the evolution of antimicrobial resistance
A Wong - Frontiers in Microbiology, 2017 - frontiersin.org
The fitness effects of a mutation can depend, sometimes dramatically, on genetic
background; this phenomenon is often referred to as “epistasis.” Epistasis can have …
background; this phenomenon is often referred to as “epistasis.” Epistasis can have …
Characterization of the microbial resistome in conventional and “raised without antibiotics” beef and dairy production systems
Metagenomic investigations have the potential to provide unprecedented insights into
microbial ecologies, such as those relating to antimicrobial resistance (AMR). We …
microbial ecologies, such as those relating to antimicrobial resistance (AMR). We …
Hypermutator Pseudomonas aeruginosa exploits multiple genetic pathways to develop multidrug resistance during long-term infections in the airways of cystic fibrosis …
CA Colque, AG Albarracín Orio, S Feliziani… - Antimicrobial agents …, 2020 - journals.asm.org
Pseudomonas aeruginosa exploits intrinsic and acquired resistance mechanisms to resist
almost every antibiotic used in chemotherapy. Antimicrobial resistance in P. aeruginosa …
almost every antibiotic used in chemotherapy. Antimicrobial resistance in P. aeruginosa …
Steering phages to combat bacterial pathogens
A critical issue facing humanity is the rise in antimicrobial resistance. Although increasing
research effort is spent on develo** novel drugs, few alternatives reach the clinic. Phage …
research effort is spent on develo** novel drugs, few alternatives reach the clinic. Phage …
[HTML][HTML] Antibiotic persistence as a metabolic adaptation: stress, metabolism, the host, and new directions
Persistence is a phenomenon during which a small fraction of a total bacterial population
survives treatment with high concentrations of antibiotics for an extended period of time. In …
survives treatment with high concentrations of antibiotics for an extended period of time. In …