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Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy
Humoral immune responses are characterized by complex mixtures of polyclonal antibody
species varying in their isotype, target epitope specificity and affinity. Posttranslational …
species varying in their isotype, target epitope specificity and affinity. Posttranslational …
[HTML][HTML] IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy
Immunoglobulin (IgG) glycosylation is a complex enzymatically controlled process, essential
for the structure and function of IgG. IgG glycome is relatively stable in the state of …
for the structure and function of IgG. IgG glycome is relatively stable in the state of …
Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity
MD Larsen, EL de Graaf, ME Sonneveld, HR Plomp… - Science, 2021 - science.org
INTRODUCTION Antibody function is often considered static and mostly determined by
isotype and subclass. The conserved N-linked glycan at position 297 in the Fc domain of …
isotype and subclass. The conserved N-linked glycan at position 297 in the Fc domain of …
[HTML][HTML] Immunoglobulin G glycosylation in aging and diseases
Abstract The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows
a significant degree of variation within populations. IgG glycome composition is influenced …
a significant degree of variation within populations. IgG glycome composition is influenced …
Impact of structural modifications of IgG antibodies on effector functions
T Damelang, M Brinkhaus, TLJ van Osch… - Frontiers in …, 2024 - frontiersin.org
Immunoglobulin G (IgG) antibodies are a critical component of the adaptive immune system,
binding to and neutralizing pathogens and other foreign substances. Recent advances in …
binding to and neutralizing pathogens and other foreign substances. Recent advances in …
IgG subclasses and allotypes: from structure to effector functions
Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human
serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ …
serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ …
Decoding the human immunoglobulin G-glycan repertoire reveals a spectrum of Fc-receptor-and complement-mediated-effector activities
Glycosylation of the immunoglobulin G (IgG)-Fc tail is required for binding to Fc-gamma
receptors (FcγRs) and complement-component C1q. A variety of IgG1-glycoforms is …
receptors (FcγRs) and complement-component C1q. A variety of IgG1-glycoforms is …
The “less-is-more” in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity
NA Pereira, KF Chan, PC Lin, Z Song - MAbs, 2018 - Taylor & Francis
Therapeutic monoclonal antibodies are the fastest growing class of biological therapeutics
for the treatment of various cancers and inflammatory disorders. In cancer immunotherapy …
for the treatment of various cancers and inflammatory disorders. In cancer immunotherapy …
Unique carbohydrate–carbohydrate interactions are required for high affinity binding between FcγRIII and antibodies lacking core fucose
C Ferrara, S Grau, C Jäger, P Sondermann… - Proceedings of the …, 2011 - pnas.org
Antibody-mediated cellular cytotoxicity (ADCC), a key immune effector mechanism, relies on
the binding of antigen–antibody complexes to Fcγ receptors expressed on immune cells …
the binding of antigen–antibody complexes to Fcγ receptors expressed on immune cells …
Functional diversification of IgGs through Fc glycosylation
IgG antibodies are secreted from B cells and bind to a variety of pathogens to control
infections as well as contribute to inflammatory diseases. Many of the functions of IgGs are …
infections as well as contribute to inflammatory diseases. Many of the functions of IgGs are …