The advent of clustered regularly interspaced short palindromic repeat (CRISPR) genome
editing, coupled with advances in computing and imaging capabilities, has initiated a new …

The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …

The perception of fat evokes strong appetitive and consummatory responses. Here we show
that fat stimuli can induce behavioural attraction even in the absence of a functional taste …

Since it was first recognized in bacteria and archaea as a mechanism for innate viral
immunity in the early 2010s, clustered regularly interspaced short palindromic repeats …

Diabetes mellitus is prevalent among women of reproductive age, and many women are left
undiagnosed or untreated. Gestational diabetes has profound and enduring effects on the …

Distant-acting tissue-specific enhancers, which regulate gene expression, vastly outnumber
protein-coding genes in mammalian genomes, but the functional importance of this …

Heparin-induced thrombocytopenia/thrombosis (HIT) is a serious immune reaction to
heparins, characterized by thrombocytopenia and often severe thrombosis with high …

Kynurenic acid (KynA) is tissue protective in cardiac, cerebral, renal, and retinal ischemia
models, but the mechanism is unknown. KynA can bind to multiple receptors, including the …

The intestinal mucosa serves both as a conduit for the uptake of food-derived nutrients and
microbiome-derived metabolites, and as a barrier that prevents tissue invasion by …

Abstract The N6-methyladenosine (m 6 A) modification is the most prevalent post-
transcriptional mRNA modification, regulating mRNA decay and splicing. It plays a major …