Introduction The nose has been receiving increased attention as a route for drug delivery. As
the site of deposition constitutes the first point of contact of the body with the drug …

Spray atomization process involves complex multi-phase phenomena. Abundant literature
and validation of spray modeling for industrial applications like fuel injection in internal …

The objectives of this study were to expand and implement a Computational Fluid Dynamics
(CFD)-Dissolution, Absorption and Clearance (DAC)-Pharmacokinetics (PK) multi-physics …

Delivery of drugs to the lungs is commonly achieved using nasal and/or oral breathing-
assisted techniques. The route of inhalation can substantially change the fate of inhaled …

Nasal sprays, which produce relatively large pharmaceutical droplets and have high
momentum, are primarily used to deliver locally acting drugs to the nasal mucosa …

Computational fluid dynamics (CFD) has been used to investigate the intranasal deposition
of corticosteroid sprays. CFD Lagrangian tracking models terminate particle motion once …

Momentum transfer from nasal spray droplets to the surrounding gas may create droplet
cloud motion and influence nasal deposition patterns. The objective of this study was to …

Nasal sprays are typically characterized using in vitro spray metrics such as spray cone
angle and droplet size distribution. It is currently not clear how these in vitro metrics correlate …

Intranasal corticosteroid sprays (ICSs) are frequently prescribed for allergic rhinitis (AR),
which is the fifth most common chronic disease in the United States. This study aimed to …

Purpose The objective of this study was to incorporate a passive cyclic loading strategy into
the infant air-jet dry powder inhaler (DPI) in a manner that provides high efficiency aerosol …