Antiseizure drugs (ASDs) prevent the occurrence of seizures; there is no evidence that they
have disease-modifying properties. In the more than 160 years that orally administered …

Epilepsy is a chronic disease that affects millions of people worldwide. Antiepileptic drugs
(AEDs) are used to control seizures. Even though parts of their mechanisms of action are …

Here, we show that the synaptic vesicle protein SV2A is the brain binding site of
levetiracetam (LEV), a new antiepileptic drug with a unique activity profile in animal models …

Drug‐resistant epilepsy with uncontrolled severe seizures despite state‐of‐the‐art medical
treatment continues to be a major clinical problem for up to one in three patients with …

The combination of brain stimulation techniques like transcranial magnetic stimulation (TMS)
with CNS active drugs in humans now offers a unique opportunity to explore the physiologic …

The global introduction of 14 new antiepileptic drugs (AEDs) over the past 20 years as
adjunctive treatment in refractory epilepsy has triggered an increased interest in optimising …

Abstract Levetiracetam (Keppra®, E Keppra®) is an established second-generation anti-
epileptic drug (AED). Worldwide, levetiracetam is most commonly approved as adjunctive …

Antiepileptic drugs (AEDs) are effective against seizures, but their use is often limited by
adverse effects, among them psychiatric and behavioral ones including aggressive behavior …

Epilepsy is a common chronic disorder that requires long-term antiepileptic drug therapy.
Approximately one half of patients fail the initial antiepileptic drug and about 35% are …

Background: Epilepsy is a chronic brain disease that is caused by various factors and
characterized by recurrent, episodic and temporary central nervous system dysfunction …