The Challenge of overcoming antibiotic resistance in carbapenem-resistant Gram-negative bacteria:“Attack on Titan”

G Mancuso, S De Gaetano, A Midiri, S Zummo… - Microorganisms, 2023 - mdpi.com
The global burden of bacterial resistance remains one of the most serious public health
concerns. Infections caused by multidrug-resistant (MDR) bacteria in critically ill patients …

Treating urinary tract infections in the era of antibiotic resistance

N Frimodt-Møller, L Bjerrum - Expert Review of Anti-infective …, 2023 - Taylor & Francis
ABSTRACT Introduction Urinary tract infections (UTIs) are associated with 25–40% of
antibiotics consumed in primary care and are, therefore, driving antibiotic resistance. The …

Mobilization of the blaKPC-14 gene among heterogenous plasmids in extensively drug-resistant hypervirulent Klebsiella pneumoniae

L Wang, W Shen, J Cai - Frontiers in microbiology, 2023 - frontiersin.org
Introduction Ceftazidime/avibactam (CZA) is an effective alternative for the treatment of
infections caused by KPC-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) …

[HTML][HTML] Attributable mortality of infections caused by carbapenem-resistant Enterobacterales: results from a prospective, multinational case-control-control matched …

M Paniagua-García, JM Bravo-Ferrer… - Clinical Microbiology …, 2024 - Elsevier
Objectives To assess the mortality attributable to infections caused by carbapenem-resistant
Enterobacterales (CRE) and to investigate the effect of clinical management on differences …

Efficacy and safety of a structured de-escalation from antipseudomonal β-lactams in bloodstream infections due to Enterobacterales (SIMPLIFY): an open-label …

LE López-Cortés, M Delgado-Valverde… - The Lancet Infectious …, 2024 - thelancet.com
Background De-escalation from broad-spectrum to narrow-spectrum antibiotics is
considered an important measure to reduce the selective pressure of antibiotics, but a …

[HTML][HTML] Epidemiology, risk factors, and clinical outcomes of carbapenem resistant Enterobacterales in Africa: A systematic review

M Kedišaletše, D Phumuzile, D Angela… - Journal of Global …, 2023 - Elsevier
Abstract Background Carbapenem-resistant Enterobacterales (CRE) commonly cause
hospital-acquired infections and hospital outbreaks worldwide, with an alarming increase in …

First report of a bla NDM-producing extensively drug resistant Klebsiella pneumoniae ST437 in Italy

SC Ranieri, V Fabbrizi, AM D'Amario… - Frontiers in Cellular …, 2024 - frontiersin.org
Carbapenemase-producing Klebsiella pneumoniae strains (CP-Kps) have recently been
observed to spread rapidly worldwide. New Delhi metallo-β-lactamase (NDM) producing …

[HTML][HTML] Carbapenem-Resistant Enterobacterales

HZ Smith, CM Hollingshead, B Kendall - StatPearls [Internet], 2024 - ncbi.nlm.nih.gov
Objectives: Select appropriate treatment options for a patient with carbapenem-resistant
Enterobacterales infections. Identify the reasons for a delayed diagnosis of carbapenem …

Risk factors of Carbapenem-resistant Enterobacterales intestinal colonization for subsequent infections in hematological patients: a retrospective case-control study

Z Wang, C Shao, J Shao, Y Hao, Y ** - Frontiers in Microbiology, 2024 - frontiersin.org
Objective Infections caused by Carbapenem-resistant Enterobacterales (CRE) have high
treatment costs, high mortality and few effective therapeutic agents. This study aimed to …

[HTML][HTML] Carbapenem-Resistant Enterobacteriaceae Bacteremia in Pediatric Patients in Latin America and the Caribbean: A Systematic Review and Meta-Analysis

S Ruvinsky, C Voto, M Roel, V Portillo… - Antibiotics, 2024 - mdpi.com
Background: Data on the health impact of carbapenem-resistant Enterobacteriaceae
bloodstream infections (CRE-BSIs) in pediatric populations from Latin America and the …