[HTML][HTML] TRPA1-Related Diseases and Applications of Nanotherapy
D Yang - International Journal of Molecular Sciences, 2024 - mdpi.com
Transient receptor potential (TRP) channels, first identified in Drosophila in 1969, are
multifunctional ion channels expressed in various cell types. Structurally, TRP channels …
multifunctional ion channels expressed in various cell types. Structurally, TRP channels …
Exploring the complex and multifaceted interplay between melanoma cells and the tumor microenvironment
M Kuras - International Journal of Molecular Sciences, 2023 - mdpi.com
Malignant melanoma is a very aggressive skin cancer, characterized by a heterogeneous
nature and high metastatic potential. The incidence of melanoma is continuously increasing …
nature and high metastatic potential. The incidence of melanoma is continuously increasing …
[HTML][HTML] Classification of the tumor immune microenvironment and associations with outcomes in patients with metastatic melanoma treated with immunotherapies
Background Tumor microenvironment (TME) characteristics are potential biomarkers of
response to immune checkpoint inhibitors in metastatic melanoma. This study developed a …
response to immune checkpoint inhibitors in metastatic melanoma. This study developed a …
FcγRIIB is an immune checkpoint limiting the activity of treg-targeting antibodies in the tumor microenvironment
Preclinical murine data indicate that fragment crystallizable (Fc)-dependent depletion of
intratumoral regulatory T cells (Treg) is a major mechanism of action of anti–CTLA-4 …
intratumoral regulatory T cells (Treg) is a major mechanism of action of anti–CTLA-4 …
Unveiling efferocytosis-related signatures through the integration of single-cell analysis and machine learning: a predictive framework for prognosis and …
T Liu, C Li, J Zhang, H Hu, C Li - Frontiers in Immunology, 2023 - frontiersin.org
Background Hepatocellular carcinoma (HCC) represents a prominent gastrointestinal
malignancy with a grim clinical outlook. In this regard, the discovery of novel early …
malignancy with a grim clinical outlook. In this regard, the discovery of novel early …
Genomic and Epigenomic Biomarkers of Immune Checkpoint Immunotherapy Response in Melanoma: Current and Future Perspectives
Immune checkpoint inhibitors (ICIs) demonstrate durable responses, long-term survival
benefits, and improved outcomes in cancer patients compared to chemotherapy. However …
benefits, and improved outcomes in cancer patients compared to chemotherapy. However …
Botensilimab, an Fc-Enhanced Anti–CTLA-4 Antibody, Is Effective against Tumors Poorly Responsive to Conventional Immunotherapy
Conventional immune checkpoint inhibitors (ICI) targeting cytotoxic T-lymphocyte antigen 4
(CTLA-4) elicit durable survival but primarily in patients with immune-inflamed tumors …
(CTLA-4) elicit durable survival but primarily in patients with immune-inflamed tumors …
Antigen presenting cells in cancer immunity and mediation of immune checkpoint blockade
Antigen-presenting cells (APCs) are pivotal mediators of immune responses. Their role has
increasingly been spotlighted in the realm of cancer immunology, particularly as our …
increasingly been spotlighted in the realm of cancer immunology, particularly as our …
Tissue-Based Profiling Techniques to Achieve Precision Medicine in Cancer: Opportunities and Challenges in Melanoma
Immunotherapies targeting the programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte
antigen 4 (CTLA-4) checkpoint receptors have revolutionized the treatment of metastatic …
antigen 4 (CTLA-4) checkpoint receptors have revolutionized the treatment of metastatic …
[HTML][HTML] Targeting tumor-associated macrophages: novel insights into immunotherapy of skin cancer
J Liu, J Lu, L Wu, T Zhang, J Wu, L Li, Z Tai… - Journal of Advanced …, 2025 - Elsevier
Background The incidence of skin cancer is currently increasing, and conventional treatment
options inadequately address the demands of disease management. Fortunately, the recent …
options inadequately address the demands of disease management. Fortunately, the recent …