From Low to No O2-Dependent Hypoxia Photodynamic Therapy (hPDT): A New Perspective

M Li, Y Xu, X Peng, JS Kim - Accounts of Chemical Research, 2022 - ACS Publications
Conspectus The advent of photochemical techniques has revolutionized the landscape of
biology and medical sciences. Especially appealing in this context is photodynamic therapy …

Photon-controlled pyroptosis activation (photopyro): an emerging trigger for antitumor immune response

M Li, J Kim, H Rha, S Son, MS Levine… - Journal of the …, 2023 - ACS Publications
Pyroptosis refers to the process of gasdermin-mediated lytic programmed cell death (PCD)
characterized by the release of pro-inflammatory cytokines. Our knowledge of pyroptosis has …

Theranostic fluorescent probes

A Sharma, P Verwilst, M Li, D Ma, N Singh… - Chemical …, 2024 - ACS Publications
The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …

Lutetium texaphyrin–celecoxib conjugate as a potential immuno-photodynamic therapy agent

J An, KP Lv, CV Chau, JH Lim, R Parida… - Journal of the …, 2024 - ACS Publications
Immuno-photodynamic therapy (IPDT) has emerged as a new modality for cancer treatment.
Novel photosensitizers can help achieve the promise inherent in IPDT, namely, the complete …

RNA-activatable near-infrared photosensitizer for cancer therapy

Y Jiang, S Huang, H Ma, J Weng, X Du… - Journal of the …, 2024 - ACS Publications
Photodynamic therapy (PDT) has recently come to the forefront as an exceptionally powerful
and promising method for the treatment of cancer. Existing photosensitizers are …

High Entropy 2D Layered Double Hydroxide Nanosheet Toward Cascaded Nanozyme-Initiated Chemodynamic and Immune Synergistic Therapy

C Wang, F Yuan, Z Yan, T Zhang, C Fu… - Journal of the …, 2024 - ACS Publications
High-entropy nanomaterials (HEMs) are a hot topic in the fields of energy and catalysis.
However, in terms of promising biomedical applications, potential therapeutic studies …

Nickel(II) Phototheranostics: A Case Study in Photoactivated H2O2-Enhanced Immunotherapy

R Zhang, H Xu, Y Yao, G Ran, W Zhang… - Journal of the …, 2023 - ACS Publications
Phototheranostics have emerged as a promising subset of cancer theranostics owing to their
potential to provide precise photoinduced diagnoses and therapeutic outcomes. However …

Overcoming the Oxygen Dilemma in Photoredox Catalysis: Near‐Infrared (NIR) Light‐Triggered Peroxynitrite Generation for Antibacterial Applications

Z Shen, S Zheng, Y Fang, G Zhang… - Angewandte Chemie …, 2023 - Wiley Online Library
The peroxynitrite anion (ONOO−) is closely associated with many diseases and the creation
of ONOO− donors is an essential means of understanding its pathophysiological functions …

Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium (III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and …

J Kasparkova, A Hernández-García… - Journal of Medicinal …, 2023 - ACS Publications
A second-generation series of biscyclometalated 2-(5-aryl-thienyl)-benzimidazole and-
benzothiazole Ir (III) dppz complexes [Ir (C^ N) 2 (dppz)]+, Ir1–Ir4, were rationally designed …

Photo-controllable biochemistry: Exploiting the photocages in phototherapeutic window

H **ong, Y Xu, B Kim, H Rha, B Zhang, M Li, GF Yang… - Chem, 2023 - cell.com
Photochemical tools have revolutionized the landscape of biomedicine, enabling the
exploration of nature in a noninvasively remote-controlled manner. Among them, especially …