Chronic stressful life events are risk factors for develo** major depression, the
pathophysiology of which is strongly linked to impairments in serotonin (5-HT) …

OBJECTIVE: The authors conducted a meta-analysis of relevant data from primary studies of
the genetic epidemiology of major depression. METHOD: The authors searched MEDLINE …

In the field of depression, inflammation-associated depression stands up as an exception
since its causal factors are obvious and it is easy to mimic in an animal model. In addition …

This review discusses neurobiological and psychosocial factors associated with stress-
induced depression and compares these factors with those believed to characterize stress …

An essential component of the human diet, L-tryptophan is critical in a number of metabolic
functions and has been widely used in numerous research and clinical trials. This review …

The monoamine hypothesis of depression predicts that the underlying pathophysiologic
basis of depression is a depletion in the levels of serotonin, norepinephrine, and/or …

The limited success of genetic studies of major depression has raised questions concerning
the definition of genetically relevant phenotypes. This paper presents strategies to improve …

Dysfunction in the monoamine systems of serotonin (5-HT), norepinephrine (NE) and
dopamine (DA) may causally be related to major depressive disorder (MDD). Monoamine …

Rates of serotonin synthesis were measured in the human brain using positron emission
tomography. The sensitivity of the method is indicated by the fact that measurements are …

Epidemiological and clinical data indicate high comorbidity between depression and drug
dependence that may reflect an attempt to self-medicate with drugs of abuse. The present …