Thrombolysis for acute ischaemic stroke: current status and future perspectives

G Tsivgoulis, AH Katsanos, EC Sandset, G Turc… - The Lancet …, 2023 - thelancet.com
Alteplase is currently the only approved thrombolytic agent for treatment of acute ischaemic
stroke, but interest is burgeoning in the development of new thrombolytic agents for systemic …

Clinically ineffective reperfusion after endovascular therapy in acute ischemic stroke

X Nie, X Leng, Z Miao, M Fisher, L Liu - Stroke, 2023 - Am Heart Assoc
Endovascular treatment is a highly effective therapy for acute ischemic stroke due to large
vessel occlusion. However, in clinical practice, nearly half of the patients do not have …

Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint …

P Yang, L Song, Y Zhang, X Zhang, X Chen, Y Li… - The Lancet, 2022 - thelancet.com
Background The optimum systolic blood pressure after endovascular thrombectomy for
acute ischaemic stroke is uncertain. We aimed to compare the safety and efficacy of blood …

Adjunctive intravenous Argatroban or Eptifibatide for ischemic stroke

O Adeoye, J Broderick, CP Derdeyn… - … England Journal of …, 2024 - Mass Medical Soc
Background Intravenous thrombolysis is a standard treatment of acute ischemic stroke. The
efficacy and safety of combining intravenous thrombolysis with argatroban (an anticoagulant …

Endovascular management of acute stroke

TN Nguyen, M Abdalkader, U Fischer, Z Qiu, S Nagel… - The Lancet, 2024 - thelancet.com
Stroke related to large vessel occlusion is a leading cause of disability and death worldwide.
Advances in endovascular therapy to reopen occluded arteries have been shown to reduce …

No-reflow phenomenon in stroke patients: a systematic literature review and meta-analysis of clinical data

A Mujanovic, F Ng, TR Meinel… - … Journal of Stroke, 2024 - journals.sagepub.com
Background: The no-reflow phenomenon refers to the absence of microvascular reperfusion
despite macrovascular reperfusion. Aim: The aim of this analysis was to summarize the …

[HTML][HTML] Risk factors, pathophysiologic mechanisms, and potential treatment strategies of futile recanalization after endovascular therapy in acute ischemic stroke

G Deng, Y Chu, J **ao, K Shang, LQ Zhou… - Aging and …, 2023 - ncbi.nlm.nih.gov
Endovascular therapy is the first-line treatment for acute ischemic stroke. However, studies
have shown that, even with the timely opening of occluded blood vessels, nearly half of all …

Acute ischaemic stroke: recent advances in reperfusion treatment

P Widimsky, K Snyder, J Sulzenko… - European Heart …, 2023 - academic.oup.com
Abstract During the last 5–7 years, tremendous progress was achieved in the reperfusion
treatment of acute ischaemic stroke during its first few hours from symptom onset. This …

Endovascular thrombectomy for basilar artery occlusion: translating research findings into clinical practice

F Alemseged, TN Nguyen, SB Coutts… - The Lancet …, 2023 - thelancet.com
Background Basilar artery occlusion is a rare and severe condition. The effectiveness of
endovascular thrombectomy in patients with basilar artery occlusion was unclear until …

No-reflow post-recanalization in acute ischemic stroke: mechanisms, measurements, and molecular markers

CP Sperring, WM Savage, MG Argenziano, VP Leifer… - Stroke, 2023 - Am Heart Assoc
Acute ischemic stroke remains the primary cause of disability worldwide. For patients with
large vessel occlusions, intravenous thrombolysis followed by mechanical thrombectomy …