Pharmacological potential of varinic-, minor-, and acidic phytocannabinoids

R Franco, R Rivas-Santisteban, I Reyes-Resina… - Pharmacological …, 2020 - Elsevier
While natural Δ 9-tetrahidrocannabinol (Δ 9 THC), cannabidiol (CBD), and their therapeutic
potential have been extensively researched, some cannabinoids have been less extensively …

Emerging strategies targeting CB2 cannabinoid receptor: Biased agonism and allosterism

P Morales, P Goya, N Jagerovic - Biochemical pharmacology, 2018 - Elsevier
During these last years, the CB 2 cannabinoid receptor has emerged as a potential anti-
inflammatory target in diseases such as multiple sclerosis, amyotrophic lateral sclerosis …

Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2 Receptors

E Martínez-Pinilla, K Varani, I Reyes-Resina… - Frontiers in …, 2017 - frontiersin.org
The mechanism of action of cannabidiol (CBD), the main non-psychotropic component of
Cannabis sativa L., is not completely understood. First assumed that the compound was …

Pharmacological data of cannabidiol-and cannabigerol-type phytocannabinoids acting on cannabinoid CB1, CB2 and CB1/CB2 heteromer receptors

G Navarro, K Varani, A Lillo, F Vincenzi… - Pharmacological …, 2020 - Elsevier
Background Recent approved medicines whose active principles are Δ 9
Tetrahidrocannabinol (Δ 9-THC) and/or cannabidiol (CBD) open novel perspectives for …

Cannabigerol Action at Cannabinoid CB1 and CB2 Receptors and at CB1–CB2 Heteroreceptor Complexes

G Navarro, K Varani, I Reyes-Resina… - Frontiers in …, 2018 - frontiersin.org
Cannabigerol (CBG) is one of the major phytocannabinoids present in Cannabis sativa L.
that is attracting pharmacological interest because it is non-psychotropic and is abundant in …

Energy transfer from antenna ligand to europium (III) followed using ultrafast optical and X-ray spectroscopy

MW Mara, DS Tatum, AM March, G Doumy… - Journal of the …, 2019 - ACS Publications
A series of highly luminescent europium (III) complexes which exhibit photoluminescence
from the Eu (III) center following energy transfer from the UV absorbing organic sensitizer …

Development of high-specificity fluorescent probes to enable cannabinoid type 2 receptor studies in living cells

RC Sarott, MV Westphal, P Pfaff, C Korn… - Journal of the …, 2020 - ACS Publications
Pharmacological modulation of cannabinoid type 2 receptor (CB2R) holds promise for the
treatment of numerous conditions, including inflammatory diseases, autoimmune disorders …

[HTML][HTML] Similarities and differences upon binding of naturally occurring Δ9-tetrahydrocannabinol-derivatives to cannabinoid CB1 and CB2 receptors

I Raïch, R Rivas-Santisteban, A Lillo, J Lillo… - Pharmacological …, 2021 - Elsevier
We have here assessed, using Δ 9-tetrahydrocannabinol (Δ 9-THC) for comparison, the
effect of Δ 9-tetrahydrocannabinolic acid (Δ 9-THCA) and of Δ 9-tetrahydrocannabivarin (Δ9 …

Cannabidiol inhibits sucrose self‐administration by CB 1 and CB 2 receptor mechanisms in rodents

GH Bi, E Galaj, Y He, ZX ** - Addiction biology, 2020 - Wiley Online Library
A growing number of studies suggest therapeutic applications of cannabidiol (CBD), a
recently US Food and Drug Administration (FDA)–approved medication for epilepsy, in …

Gut microbiota, cannabinoid system and neuroimmune interactions: New perspectives in multiple sclerosis

L Mestre, FJ Carrillo-Salinas, M Mecha, A Feliú… - Biochemical …, 2018 - Elsevier
The gut microbiota plays a fundamental role on the education and function of the host
immune system. Immunological dysregulation is the cause of numerous human disorders …