Current and future role of MRI in the diagnosis and prognosis of multiple sclerosis

MA Rocca, P Preziosa, F Barkhof… - The Lancet Regional …, 2024‏ - thelancet.com
In the majority of cases, multiple sclerosis (MS) is characterized by reversible episodes of
neurological dysfunction, often followed by irreversible clinical disability. Accurate diagnostic …

Typical and Emerging Diagnostic MRI Features in Multiple Sclerosis

À Rovira, C Auger, S Sceppacuercia… - Canadian Association …, 2025‏ - journals.sagepub.com
Magnetic resonance imaging (MRI) stands as the most sensitive paraclinical technique for
detecting the demyelinating lesions characteristic of multiple sclerosis (MS). Consequently …

Choroid plexus volume differentiates MS from its mimics

E Levit, Z Ren, V Gonzenbach… - Multiple Sclerosis …, 2024‏ - journals.sagepub.com
This study aimed to determine whether choroid plexus volume (CPV) could differentiate
multiple sclerosis (MS) from its mimics. A secondary analysis of two previously enrolled …

Diagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis

K Toljan, L Daboul, P Raza, ML Martin… - Multiple Sclerosis …, 2024‏ - journals.sagepub.com
Background: Cerebrospinal fluid (CSF) oligoclonal bands (OCB) are a diagnostic biomarker
in multiple sclerosis (MS). The central vein sign (CVS) is an imaging biomarker for MS that …

Incorporating the central vein sign into the diagnostic criteria for multiple sclerosis

D Ontaneda, JA Cohen, P Sati - JAMA neurology, 2023‏ - jamanetwork.com
The diagnosis of multiple sclerosis (MS), which is codified in the McDonald criteria, 1 relies
on demonstration of dissemination in space (DIS) and dissemination in time (DIT) following …

Multicenter validation of automated detection of paramagnetic rim lesions on brain MRI in multiple sclerosis

L Chen, Z Ren, KA Clark, C Lou, F Liu… - Journal of …, 2024‏ - Wiley Online Library
Abstract Background and Purpose Paramagnetic rim lesions (PRLs) are an MRI biomarker
of chronic inflammation in people with multiple sclerosis (MS). PRLs may aid in the …

Multicenter automated central vein sign detection performs as well as manual assessment for the diagnosis of multiple sclerosis

AR Manning, V Letchuman, ML Martin… - American Journal of …, 2024‏ - ajnr.org
ABSTRACT BACKGROUND AND PURPOSE: The central vein sign (CVS) is a proposed
diagnostic imaging biomarker for multiple sclerosis (MS). The proportion of white matter …

Reliability of Central Vein Sign Imaging With 3T FLAIR* in a Multicenter Study

ML Martin, Q Cao, E Luskin, B Renner… - Journal of …, 2025‏ - Wiley Online Library
ABSTRACT Background and Purpose The central vein sign (CVS) is a diagnostic imaging
biomarker for multiple sclerosis (MS). FLAIR* is a combined MRI contrast that provides high …

Incorporation of the central vein sign into the McDonald criteria

M Amin, K Nakamura, L Daboul, C O'Donnell… - Multiple Sclerosis and …, 2025‏ - Elsevier
Background Diagnosis of multiple sclerosis (MS) frequently relies on MRI dissemination in
time (DIT) and space (DIS), as codified in 2017 McDonald criteria (McD 2017). The central …

The “central vein sign” to differentiate multiple sclerosis from migraine

G Silvestri, L Roccatagliata, F Tazza… - … : The Journal of …, 2022‏ - Wiley Online Library
Objective To investigate, in two cohorts including patients with multiple sclerosis (MS) and
migraine,(i) the prevalence of the “central vein sign”(CVS),(ii) the spatial distribution of …