Highly dynamic mitotic-spindle microtubules are among the most successful targets for
anticancer therapy. Microtubule-targeted drugs, including paclitaxel and Vinca alkaloids …

For over 40 years, natural products have served us well in combating cancer. The main
sources of these successful compounds are microbes and plants from the terrestrial and …

Natural products and their derivatives have historically been invaluable as a source of
therapeutic agents. However, in the past decade, research into natural products in the …

Drug discovery from marine natural products has enjoyed a renaissance in the past few
years. Ziconotide (Prialt; Elan Pharmaceuticals), a peptide originally discovered in a tropical …

In recent years, marine natural product bioprospecting has yielded a considerable number
of drug candidates. Most of these molecules are still in preclinical or early clinical …

Since its approval by the FDA in 1992 for the treatment of ovarian cancer, the use of Taxol
has dramatically increased. Although treatment with Taxol has led to improvement in the …

Multidrug resistance (MDR) is regarded as one of the bottlenecks of successful clinical
treatment for numerous chemotherapeutic agents. Multiple key regulators are alleged to be …

Chemical compounds that interfere with microtubules such as the vinca alkaloids and
taxanes are important chemotherapeutic agents for the treatment of cancer. As our …

Microtubules are dynamic polymers that play crucial roles in a large number of cellular
functions. Their pivotal role in mitosis makes them a target for the development of anticancer …

Despite the huge investment into research and the significant effort and advances made in
the search for new anticancer drugs in recent decades, cancer cure and treatment continue …