A diverse array of sex determination (SD) mechanisms, encompassing environmental to
genetic, have been found to exist among vertebrates, covering a spectrum from fixed SD …

The discovery of the Sry gene in 1990 triggered a revolution in our understanding of sex
determination. More recently, advances in non-model organisms have been fuelled by the …

Environmental sex determination (ESD) occurs in divergent, phylogenetically unrelated taxa,
and in some species, co-occurs with genetic sex determination (GSD) mechanisms …

Epigenetics is commonly defined as the study of heritable changes in gene function that
cannot be explained by changes in DNA sequence. The three major epigenetic mechanisms …

Although the genetic triggers for gonadal sex differentiation vary across species, the cell
biology of gonadal development was long thought to be largely conserved. Here, we present …

Sexual fate is no longer seen as an irreversible deterministic switch set during early
embryonic development but as an ongoing battle for primacy between male and female …

Teleost fishes are the most species-rich clade of vertebrates and feature an overwhelming
diversity of sex-determining mechanisms, classically grouped into environmental and …

The spermatozoa and oocyte are very specialized cells which possess the unique ability to
fuse and to produce an embryo. This embryo will develop into a mature organism capable of …

Understanding sex determining (SD) mechanisms and related concepts in a wide range of
fish species is critical for sex control and large‐scale monosex production in aquaculture, in …

In mammalian embryonic gonads, SOX9 is required for the determination of Sertoli cells that
orchestrate testis morphogenesis. To identify genetic networks directly regulated by SOX9 …