The role of 3D genome organization in development and cell differentiation
H Zheng, W ** and annotation of genetic associations with FUMA
K Watanabe, E Taskesen, A Van Bochoven… - Nature …, 2017 - nature.com
A main challenge in genome-wide association studies (GWAS) is to pinpoint possible causal
variants. Results from GWAS typically do not directly translate into causal variants because …
variants. Results from GWAS typically do not directly translate into causal variants because …
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular
disease. We report the largest genetic association study of blood pressure traits (systolic …
disease. We report the largest genetic association study of blood pressure traits (systolic …
HiGlass: web-based visual exploration and analysis of genome interaction maps
We present HiGlass, an open source visualization tool built on web technologies that
provides a rich interface for rapid, multiplex, and multiscale navigation of 2D genomic maps …
provides a rich interface for rapid, multiplex, and multiscale navigation of 2D genomic maps …
A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm
Neither the disease mechanism nor treatments for COVID-19 are currently known. Here, we
present a novel molecular mechanism for COVID-19 that provides therapeutic intervention …
present a novel molecular mechanism for COVID-19 that provides therapeutic intervention …
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Intelligence is highly heritable and a major determinant of human health and well-being.
Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …
Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …
GeneHancer: genome-wide integration of enhancers and target genes in GeneCards
A major challenge in understanding gene regulation is the unequivocal identification of
enhancer elements and uncovering their connections to genes. We present GeneHancer, a …
enhancer elements and uncovering their connections to genes. We present GeneHancer, a …
Comprehensive functional genomic resource and integrative model for the human brain
INTRODUCTION Strong genetic associations have been found for a number of psychiatric
disorders. However, understanding the underlying molecular mechanisms remains …
disorders. However, understanding the underlying molecular mechanisms remains …