[HTML][HTML] Single cell cancer epigenetics

M Casado-Pelaez, A Bueno-Costa, M Esteller - Trends in Cancer, 2022 - cell.com
Bulk sequencing methodologies have allowed us to make great progress in cancer
research. Unfortunately, these techniques lack the resolution to fully unravel the epigenetic …

[HTML][HTML] Immune dysregulation

A Long, A Kleiner, RJ Looney - Journal of Allergy and Clinical Immunology, 2023 - Elsevier
The understanding of immune dysregulation in many different diseases continues to grow.
There is increasing evidence that altered microbiome and gut barrier dysfunction contribute …

Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of …

G Godoy-Tena, A Barmada, O Morante-Palacios… - Genome Medicine, 2022 - Springer
Background COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from
asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are …

The Rapidly Expanding Genetic Spectrum of Common Variable Immunodeficiency–Like Disorders

R Ameratunga, ESJ Edwards, K Lehnert… - The Journal of Allergy …, 2023 - Elsevier
The understanding of common variable immunodeficiency disorders (CVID) is in evolution.
CVID was previously a diagnosis of exclusion. New diagnostic criteria have allowed the …

Genetics and clinical phenotypes in common variable immunodeficiency

C Cunningham-Rundles, JL Casanova… - Frontiers in …, 2024 - frontiersin.org
Common variable immunodeficiency (CVID) is one of the most common symptomatic groups
of inborn errors of immunity. In addition to infections resulting from insufficient levels of …

Interplay between epigenetic and genetic alterations in inborn errors of immunity

J Rodríguez-Ubreva, CL Calvillo, LRF Satter… - Trends in …, 2023 - cell.com
Inborn errors of immunity (IEIs) comprise a variety of immune conditions leading to
infections, autoimmunity, allergy, and cancer. Some IEIs have no identified mutation (s) …

YAP/TAZ: Molecular pathway and disease therapy

Y Wei, VLZ Hui, Y Chen, R Han, X Han, Y Guo - MedComm, 2023 - Wiley Online Library
The Yes‐associated protein and its transcriptional coactivator with PDZ‐binding motif
(YAP/TAZ) are two homologous transcriptional coactivators that lie at the center of a key …

Genomic crossroads between non-Hodgkin's lymphoma and common variable immunodeficiency

K Guevara-Hoyer, J Fuentes-Antrás… - Frontiers in …, 2022 - frontiersin.org
Common variable immunodeficiency (CVID) represents the largest group of primary
immunodeficiencies that may manifest with infections, inflammation, autoimmunity, and …

Common variable immunodeficiency, cross currents, and prevailing winds

N Romberg, C Le Coz - Immunological Reviews, 2024 - Wiley Online Library
Common variable immunodeficiency (CVID) is a heterogenous disease category created to
distinguish late‐onset antibody deficiencies from early‐onset diseases like …

COVID-19 progression and convalescence in common variable immunodeficiency patients show dysregulated adaptive immune responses and persistent type I …

J Rodríguez-Ubreva, J Calafell-Segura… - Nature …, 2024 - nature.com
Common variable immunodeficiency (CVID) is the most prevalent primary
immunodeficiency, marked by hypogammaglobulinemia, poor antibody responses, and …