Typical immune responses lead to prominent clonal expansion of antigen-specific T and B
cells followed by differentiation into effector cells. Most effector cells die at the end of the …

CD8+ T cells can differentiate into two effector phenotypes, Tc1 and Tc2, secreting different
cytokine patterns. Both subsets are cytotoxic via the perforin and Fas pathways, and both kill …

This study describes the construction of soluble major histocompatibility complexes
consisting of the mouse class I molecule, H-2Db, chemically biotinylated 2 microglobulin …

The immunosurveillance of transformed cells by the immune system remains one of the most
controversial and poorly understood areas of immunity. Gene-targeted mice have greatly …

T cell memory depends on factors that regulate expansion and death of these cells after
antigenic stimulation. Mice deficient in perforin and interferon-γ (IFN-γ) exhibited increased …

The haemophagocytic syndrome (HPS) is a rare but frequently fatal disorder of immune
regulation caused by hypercytokinemia. Using cytometric bead array technique, the serum T …

CD8+ T cells are a key component of the adaptive immune response to viral infection. An
inadequate CD8+ T cell response is thought to be partly responsible for the persistent …

Perforin defects have been identified in humans with familial hematophagocytic
lymphohistiocytosis. The pathology of these patients has dramatically illustrated an under …

Tuberculosis is the number one cause of death due to infectious disease in the world today.
Understanding the dynamics of the immune response is crucial to elaborating differences …

MHC class I-restricted antigen presentation is an essential step in the priming of CD8 T
lymphocytes during immune responses to infection. While microbial growth and clearance …