Intensiometric genetically encoded biosensors, based on allosteric modulation of the
fluorescence of a single fluorescent protein, are powerful tools for enabling imaging of …

Based on the development of automatic devices and rapid assay methods, various high-
throughput screening (HTS) strategies have been established for improving the performance …

Genetically encoded fluorescent biosensors are powerful tools used to track chemical
processes in intact biological systems. However, the development and optimization of …

Metabolite biosensors are central to current efforts toward precision engineering of
metabolism. Although most research has focused on building new biosensors, their …

Natural products and their derivatives offer a rich source of chemical and biological diversity;
however, traditional engineering of their biosynthetic pathways to improve yields and access …

The construction and assembly of artificial allosteric protein switches into information and
energy processing networks connected to both biological and non-biological systems is a …

Genetically encoded biosensors based on fluorescent proteins (FPs) are a reliable tool for
studying the various biological processes in living systems. The circular permutation of …

Genetically encoded fluorescent biosensors have revolutionized the study of cell signaling
and metabolism, as they allow for live-cell measurements with high spatiotemporal …

Biosensors are powerful tools for detecting, real-time imaging, and quantifying molecules,
but rapidly constructing diverse genetically encoded biosensors remains challenging. Here …

CRISPR-Cas systems depend on the Cas1-Cas2 integrase to capture and integrate short
foreign DNA fragments into the CRISPR locus, enabling adaptation to new viruses. We …