Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …

The human microbiota comprises trillions of symbiotic microorganisms and is involved in
regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis …

Tauopathies are a broad set of neurodegenerative dementias characterized by aggregation
of the tau protein into filamentous inclusions that can be found in neurons and glial cells …

Autophagy is a lysosomal degradative process used to recycle obsolete cellular constituents
and eliminate damaged organelles and protein aggregates. These substrates reach …

Breakthrough discoveries identifying common genetic causes for amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD) have transformed our view of these …

The progression of many neurodegenerative diseases is thought to be driven by the
template-directed misfolding, seeded aggregation and cell–cell transmission of …

For several decades scientists have speculated that the key to understanding age-related
neurodegenerative disorders may be found in the unusual biology of the prion diseases …

The multiple roles played by RNA binding proteins in neurodegeneration have become
apparent following the discovery of TAR DNA binding protein 43 kDa (TDP‐43) and fused in …

Objective To see whether the distribution patterns of phosphorylated 43kDa TAR DNA‐
binding protein (pTDP‐43) intraneuronal inclusions in amyotrophic lateral sclerosis (ALS) …

The finding that a GGGGCC (G4C2) hexanucleotide repeat expansion in the chromosome 9
ORF 72 (C9ORF72) gene is a common cause of amyotrophic lateral sclerosis (ALS) and …