The therapeutic potential of PROTACs

AB Benowitz, KL Jones, JD Harling - Expert Opinion on …, 2021 - Taylor & Francis
Introduction PROTACs represent a novel class of heterobifunctional molecules that
simultaneously bind to a target protein and to an E3 ligase complex, resulting in the transfer …

Therapeutic targeting of chromatin: status and opportunities

M Siklos, S Kubicek - The FEBS Journal, 2022 - Wiley Online Library
The molecular characterization of mechanisms underlying transcriptional control and
epigenetic inheritance since the 1990s has paved the way for the development of targeted …