Sialic acid–binding immunoglobulin-type lectins (Siglecs) are expressed on the majority of
white blood cells of the immune system and play critical roles in immune cell signaling …

The blood-brain barrier (BBB) provides a vast interface for cytokines to affect CNS function.
The BBB is a target for therapeutic intervention. It is essential, therefore, to understand how …

Autophagy and phagocytosis are conserved cellular functions involved in innate immunity.
However, the nature of their interactions remains unclear. We evaluated the role of …

Apoptotic cells are quickly recognized and engulfed by phagocytes to prevent the release of
noxious materials from dying cells. Phosphatidylserine (PS) exposed on the surface of …

IL-25 (IL-17E) is a T-helper cell type 2 (Th2) cytokine best described as a potentiator of Th2
memory responses. Reports of expression of its receptor, IL-25R, on airways structural cells …

Abstract Interleukin-7 (IL-7) is an essential cytokine for T-cell development and homeostasis.
It is well established that IL-7 promotes the transcriptional down-regulation of IL7RA, leading …

Signaling of plasma membrane receptors can be regulated by endocytosis at different
levels, including receptor internalization, endocytic sorting towards degradation or recycling …

Abstract Interleukin‐5 (IL‐5) is an interdigitating homodimeric glycoprotein that is initially
identified by its ability to support the in vitro growth and differentiation of mouse B cells and …

Psoriasis is a chronic inflammatory skin disorder effectively treated by blocking IL-17RA, a
receptor chain used by several IL-17 family members, including IL-17E. Although IL-17A is …

Eosinophils are recruited to the lung in response to infection with pneumovirus pathogens
and have been associated with both the pathophysiologic sequelae of infection and, more …