Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

Lung cancer screening

SJ Adams, E Stone, DR Baldwin, R Vliegenthart, P Lee… - The Lancet, 2023 - thelancet.com
Randomised controlled trials, including the National Lung Screening Trial (NLST) and the
NELSON trial, have shown reduced mortality with lung cancer screening with low-dose CT …

[HTML][HTML] SCLC: epidemiology, risk factors, genetic susceptibility, molecular pathology, screening, and early detection

Q Wang, ZH Gümüş, C Colarossi, L Memeo… - Journal of Thoracic …, 2023 - Elsevier
We review research regarding the epidemiology, risk factors, genetic susceptibility,
molecular pathology, and early detection of SCLC, a deadly tumor that accounts for 14% of …

Liquid biopsy for lung cancer: up-to-date and perspectives for screening programs

GMS Casagrande, MO Silva, RM Reis… - International Journal of …, 2023 - mdpi.com
Lung cancer is the deadliest cancer worldwide. Tissue biopsy is currently employed for the
diagnosis and molecular stratification of lung cancer. Liquid biopsy is a minimally invasive …

Artificial intelligence in lung cancer screening: the future is now

M Cellina, LM Cacioppa, M Cè, V Chiarpenello… - Cancers, 2023 - mdpi.com
Simple Summary Lung cancer is a widespread malignant tumour with a high mortality and
morbidity rate and is frequently diagnosed in the middle and late stages when few therapies …

Plasma protein biomarkers for early prediction of lung cancer

MPA Davies, T Sato, H Ashoor, L Hou, T Liloglou… - …, 2023 - thelancet.com
Background Individual plasma proteins have been identified as minimally invasive
biomarkers for lung cancer diagnosis with potential utility in early detection. Plasma …

[HTML][HTML] Current and future perspectives on computed tomography screening for lung cancer: a roadmap from 2023 to 2027 from the International Association for the …

S Lam, C Bai, DR Baldwin, Y Chen, C Connolly… - Journal of Thoracic …, 2024 - Elsevier
Low-dose computed tomography (LDCT) screening for lung cancer substantially reduces
mortality from lung cancer, as revealed in randomized controlled trials and meta-analyses …

CRISPR for companion diagnostics in low-resource settings

Q Xu, Q Xu, C Lyon, TY Hu - Lab on a Chip, 2024 - pubs.rsc.org
New point-of-care tests (POCTs), which are especially useful in low-resource settings, are
needed to expand screening capacity for diseases that cause significant mortality …

[HTML][HTML] Early detection of lung cancer using small RNAs

T Sikosek, R Horos, F Trudzinski, J Jehn… - Journal of Thoracic …, 2023 - Elsevier
Introduction Lung cancer remains the deadliest cancer in the world, and lung cancer survival
is heavily dependent on tumor stage at the time of detection. Low-dose computed …