Morris water maze: a versatile and pertinent tool for assessing spatial learning and memory

MZ Othman, Z Hassan, ATC Has - Experimental animals, 2022‏ - jstage.jst.go.jp
Since its development about 40 years ago (1981–2021), Morris water maze has turned into
a very popular tool for assessing spatial learning and memory. Its many advantages have …

Brain mechanisms underlying neuropsychiatric symptoms in Alzheimer's disease: a systematic review of symptom-general and–specific lesion patterns

Y Chen, M Dang, Z Zhang - Molecular Neurodegeneration, 2021‏ - Springer
Neuropsychiatric symptoms (NPSs) are common in patients with Alzheimer's disease (AD)
and are associated with accelerated cognitive impairment and earlier deaths. This review …

Neural dynamics underlying associative learning in the dorsal and ventral hippocampus

JS Biane, MA Ladow, F Stefanini, SP Boddu… - Nature …, 2023‏ - nature.com
Animals associate cues with outcomes and update these associations as new information is
presented. This requires the hippocampus, yet how hippocampal neurons track changes in …

Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus

C Anacker, VM Luna, GS Stevens, A Millette, R Shores… - Nature, 2018‏ - nature.com
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by
environmental influences, and functionally implicated in behavioural responses to stress …

Early life adversity shapes social subordination and cell type–specific transcriptomic patterning in the ventral hippocampus

A Kos, JP Lopez, J Bordes, C De Donno, J Dine… - Science …, 2023‏ - science.org
Adverse events in early life can modulate the response to additional stressors later in life
and increase the risk of develo** psychiatric disorders. The underlying molecular …

Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data

P Zhou, SL Resendez, J Rodriguez-Romaguera… - elife, 2018‏ - elifesciences.org
In vivo calcium imaging through microendoscopic lenses enables imaging of previously
inaccessible neuronal populations deep within the brains of freely moving animals …

[HTML][HTML] Vagus nerve stimulation drives selective circuit modulation through cholinergic reinforcement

S Bowles, J Hickman, X Peng, WR Williamson… - Neuron, 2022‏ - cell.com
Vagus nerve stimulation (VNS) is a neuromodulation therapy for a broad and expanding set
of neurologic conditions. However, the mechanism through which VNS influences central …

Encoding of contextual fear memory in hippocampal–amygdala circuit

WB Kim, JH Cho - Nature communications, 2020‏ - nature.com
In contextual fear conditioning, experimental subjects learn to associate a neutral context
with an aversive stimulus and display fear responses to a context that predicts danger …

Hippocampal astrocytes modulate anxiety-like behavior

WH Cho, K Noh, BH Lee, E Barcelon, SB Jun… - Nature …, 2022‏ - nature.com
Astrocytes can affect animal behavior by regulating tripartite synaptic transmission, yet their
influence on affective behavior remains largely unclear. Here we showed that hippocampal …

Single-cell activity and network properties of dorsal raphe nucleus serotonin neurons during emotionally salient behaviors

GE Paquelet, K Carrion, CO Lacefield, P Zhou, R Hen… - Neuron, 2022‏ - cell.com
The serotonin system modulates a wide variety of emotional behaviors and states, including
reward processing, anxiety, and social interaction. To reveal the underlying patterns of …