Pancreatic cancer (PC) is one of the most lethal types of cancer due to its asymptomatic
nature in the early stages and consequent late diagnosis. Its mortality rate remains high …

Background Progress in immunotherapy for pancreatic ductal adenocarcinoma (PDAC) has
been slow, yet the relationship between microorganisms and metabolites is crucial to PDAC …

Results: Mice fed the HFD progressively expanded their adipose mass accompanied by a
significant decrease in glucose tolerance (P< 0.001) and insulin sensitivity (P< 0.05). MeDIP …

Ascorbic acid induces apoptosis, autophagy, and necrotic cell death in cancer cells. We
investigated the mechanisms by which ascorbic acid induces death in laryngeal squamous …

Gastroenteropancreatic neuroendocrine neoplasia (GEP-NEN) comprises a heterogeneous
group of tumours that exhibit widely divergent biological behaviour. The identification of new …

Background Treatment with GABA or glucagon‐like peptide‐1 (GLP‐1) can preserve
pancreatic β‐cell mass and prevent diabetes. Recently, we reported that the combination of …

Progressive decline in β cell function and reduction in the β cell mass is important in type 2
diabetes. Here, we tested the hypothesis that madecassoside's previously demonstrated in …

Metabolic and/or endocrine dysfunction of the white adipose tissue (WAT) contribute to the
development of metabolic disorders, such as Type 2 Diabetes (T2D). Therefore, the …

Tyrosine hydroxylase (TH), catalyzing the conversion of tyrosine into l‐DOPA, is the rate‐
limiting enzyme in dopamine synthesis. Defects in insulin action contribute to alterations of …

Under different pathological conditions, high levels of reactive oxygen species (ROS) cause
substantial damage to multiple organs. To counter these ROS levels in multiple organs, we …