MicroRNAs (miRNAs), a class of endogenous small noncoding RNAs in eukaryotes, have
been recognized as significant regulators of gene expression through post-transcriptional …

MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively
regulating gene expression to control many cellular mechanisms. The miRTarBase …

Diabetes is a rapidly increasing global health concern that significantly strains the health
system due to its downstream complications. Dysregulation in glycemia represents one of …

Recent advances in sequencing technology have helped unveil the unexpected complexity
and diversity of small RNAs. A critical step in small RNA library preparation for sequencing is …

A decline in β-cell function is a prerequisite for the development of type 2 diabetes, yet the
level of β-cell function in individuals at risk of the condition is rarely measured. This is due, in …

Pancreatic β-cells regulate glucose metabolism by secreting insulin, which in turn stimulates
the utilization or storage of the sugar by peripheral tissues. Insulin insufficiency and a …

The progression of diabetes is accompanied by increasing demand to the beta‐cells to
produce and secrete more insulin, requiring complex beta‐cell adaptations. Functionally …

Background Resistance to platinum-based chemotherapy remains a great challenge for
ovarian cancer treatment. The human let-7 family contains 13 members located on nine …

In our previous study, advanced glycosylation end‑product specific receptor (RAGE) was
observed to bind to S100A8/A9 and cause epithelial mesenchymal transition (EMT). The …

Since their discovery in the early 1990s, microRNAs have emerged as key components of
the post-transcriptional regulation of gene expression. MicroRNAs occur in the plant and …