Standardizing designed and emergent quantitative features in microphysiological systems

DM Nahon, R Moerkens, H Aydogmus… - Nature biomedical …, 2024 - nature.com
Microphysiological systems (MPSs) are cellular models that replicate aspects of organ and
tissue functions in vitro. In contrast with conventional cell cultures, MPSs often provide …

Hippocampal subfield volumetry from structural isotropic 1 mm3 MRI scans: A note of caution

LEM Wisse, G Chételat, AM Daugherty… - Human brain …, 2021 - Wiley Online Library
Spurred by availability of automatic segmentation software, in vivo MRI investigations of
human hippocampal subfield volumes have proliferated in the recent years. However, a …

A probabilistic atlas of the human thalamic nuclei combining ex vivo MRI and histology

JE Iglesias, R Insausti, G Lerma-Usabiaga… - Neuroimage, 2018 - Elsevier
The human thalamus is a brain structure that comprises numerous, highly specific nuclei.
Since these nuclei are known to have different functions and to be connected to different …

Diagnosis of Alzheimer's disease using universum support vector machine based recursive feature elimination (USVM-RFE)

B Richhariya, M Tanveer, AH Rashid… - … Signal Processing and …, 2020 - Elsevier
Alzheimer's disease is one of the most common causes of death in today's world. Magnetic
resonance imaging (MRI) provides an efficient and non-invasive approach for diagnosis of …

A deep learning model for early prediction of Alzheimer's disease dementia based on hippocampal magnetic resonance imaging data

H Li, M Habes, DA Wolk, Y Fan… - Alzheimer's & …, 2019 - Elsevier
Introduction It is challenging at baseline to predict when and which individuals who meet
criteria for mild cognitive impairment (MCI) will ultimately progress to Alzheimer's disease …

Diffuse axonal injury has a characteristic multidimensional MRI signature in the human brain

D Benjamini, D Iacono, ME Komlosh, DP Perl… - Brain, 2021 - academic.oup.com
Axonal injury is a major contributor to the clinical symptomatology in patients with traumatic
brain injury. Conventional neuroradiological tools, such as CT and MRI, are insensitive to …

Independent and reproducible hippocampal radiomic biomarkers for multisite Alzheimer's disease: diagnosis, longitudinal progress and biological basis

K Zhao, Y Ding, Y Han, Y Fan, AF Alexander-Bloch… - Science Bulletin, 2020 - Elsevier
Hippocampal morphological change is one of the main hallmarks of Alzheimer's disease
(AD). However, whether hippocampal radiomic features are robust as predictors of …

[HTML][HTML] Test-retest reliability of FreeSurfer automated hippocampal subfield segmentation within and across scanners

EM Brown, ME Pierce, DC Clark, BR Fischl, JE Iglesias… - Neuroimage, 2020 - Elsevier
The human hippocampus is vulnerable to a range of degenerative conditions and as such,
accurate in vivo measurement of the hippocampus and hippocampal substructures via …

Three-dimensional map** of neurofibrillary tangle burden in the human medial temporal lobe

PA Yushkevich, M Muñoz López… - Brain, 2021 - academic.oup.com
Tau protein neurofibrillary tangles are closely linked to neuronal/synaptic loss and cognitive
decline in Alzheimer's disease and related dementias. Our knowledge of the pattern of …

Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes

D Van der Meer, J Rokicki, T Kaufmann… - Molecular …, 2020 - nature.com
The hippocampus is a heterogeneous structure, comprising histologically distinguishable
subfields. These subfields are differentially involved in memory consolidation, spatial …