Microbes are the leading producers of useful natural products. Natural products from
microbes and plants make excellent drugs. Significant portions of the microbial genomes are …

Secondary metabolites have been found to have interesting applications over and above
their well-known medical uses, eg, as antimicrobials, etc. These alternative applications …

Abstract The FK506-binding protein 51 (FKBP51, encoded by the FKBP5 gene) is an
established risk factor for stress-related psychiatric disorders such as major depression …

Metabolic engineering efforts toward rewiring metabolism of cells to produce new
compounds often require the utilization of non-native enzymatic machinery that is capable of …

Geldanamycin, a polyketide natural product, is of significant interest for development of new
anticancer drugs that target the protein chaperone Hsp90. While the chemically reactive …

Microbial metabolites have for decades been a rich source of natural product drug leads and
therapeutically important drugs. 1, 2 The terms 'engineered biosynthesis' and 'combinatorial …

Immunophilins consist of a family of highly conserved proteins which possess binding
abilities to immunosuppressive drugs. Cyclophilins (Cyps) and FK506-binding proteins …

Polyketides comprise one of the major families of natural products. They are found in a wide
variety of bacteria, fungi, and plants and include a large number of medically important …

The immunophilin ligands cyclosporin A, FK506 and rapamycin are best known for their
immunosuppressive properties and their clinical use in transplantation medicine. These …

No clinical techniques induce restoration of neurological losses following spinal cord
trauma. Peripheral nerve damage also leads to permanent neurological deficits, but …