IL-27, a member of the IL-6/IL-12 cytokine superfamily, is primarily secreted by antigen
presenting cells, specifically by dendric cells, macrophages and B cells. IL-27 has antiviral …

Monocytes/macrophages are a diverse group of cells that act as first responders in innate
immunity and then as mediators for adaptive immunity to help clear infections. In performing …

ABSTRACT A human immunodeficiency virus (HIV) infection cure requires an
understanding of the cellular and anatomical sites harboring virus that contribute to viral …

The spleen is a primary target of deoxynivalenol (DON) toxicity, but its underlying molecular
mechanisms remain unclear. This study investigates the effects of DON on inflammation …

Introduction: An event of increasing interest during host-pathogen interactions is the
polarization of patrolling/naive monocytes (MOs) into macrophage subsets (MФs) …

Liver disease is a leading contributor to morbidity and mortality during HIV infection, despite
the use of combination antiretroviral therapy (cART). The precise mechanisms of liver …

Abstract In healthy conditions, pannexin‐1 (Panx‐1) channels are in a close state, but in
several pathological conditions, including human immunodeficiency virus‐1 (HIV) and …

Dissemination of HIV-1 throughout lymphoid tissues leads to systemic virus spread following
infection. We combined tissue clearing, 3D-immunofluorescence, and electron tomography …

Purpose of Review HIV reservoirs are the main barrier to cure. CD4+ T cells have been
extensively studied as the primary HIV-1 reservoir. However, there is substantial evidence …

Adequate antiretroviral (ARV) concentrations in lymphoid tissues are critical for optimal
antiretroviral therapy (ART). While the spleen contains 25% of the body's lymphocytes, there …