The reprogramming of somatic cells with defined factors, which converts cells from one
lineage into cells of another, has greatly reshaped our traditional views on cell identity and …

The methods for the culture and cardiomyocyte differentiation of human embryonic stem
cells, and later human induced pluripotent stem cells (hiPSC), have moved from a complex …

The adult heart is a vital and highly specialized organ of the human body, with limited
capability of self-repair and regeneration in case of injury or disease. Engineering …

The vasculature is an essential organ for the delivery of blood and oxygen to all tissues of
the body and is thus relevant to the treatment of ischaemic diseases, injury-induced …

Induced pluripotent stem cells (iPSCs) were first generated by Yamanaka and colleagues
over a decade ago. Since then, iPSCs have been successfully differentiated into many …

Induced pluripotent stem cells (iPSCs) have the ability to differentiate into cardiomyocytes
(CMs). They are not only widely used in cardiac pharmacology screening, human heart …

The metabolic patterns and energetics of human induced pluripotent stem cell-derived
cardiomyocytes (HiPSC-CMs) are much less than those of normal adult cardiomyocytes …

Direct cardiac reprogramming from fibroblasts can be a promising approach for disease
modeling, drug screening, and cardiac regeneration in pediatric and adult patients …

Direct reprogramming of fibroblasts to alternative cell fates by forced expression of
transcription factors offers a platform to explore fundamental molecular events governing cell …

A primary limitation in the use of pluripotent stem cell‐derived cardiomyocytes (PSC‐CMs)
for both patient health and scientific investigation is the failure of these cells to achieve full …