Biophysics in tumor growth and progression: from single mechano-sensitive molecules to mechanomedicine
Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …
between the biophysical tumor microenvironment and genetic regulation has significant …
Are cancer cells really softer than normal cells?
Solid tumours are often first diagnosed by palpation, suggesting that the tumour is more rigid
than its surrounding environment. Paradoxically, individual cancer cells appear to be softer …
than its surrounding environment. Paradoxically, individual cancer cells appear to be softer …
A comparison of methods to assess cell mechanical properties
The mechanical properties of cells influence their cellular and subcellular functions,
including cell adhesion, migration, polarization, and differentiation, as well as organelle …
including cell adhesion, migration, polarization, and differentiation, as well as organelle …
[HTML][HTML] Probing the stochastic, motor-driven properties of the cytoplasm using force spectrum microscopy
Molecular motors in cells typically produce highly directed motion; however, the aggregate,
incoherent effect of all active processes also creates randomly fluctuating forces, which drive …
incoherent effect of all active processes also creates randomly fluctuating forces, which drive …
The 2019 mathematical oncology roadmap
Whether the nom de guerre is Mathematical Oncology, Computational or Systems Biology,
Theoretical Biology, Evolutionary Oncology, Bioinformatics, or simply Basic Science, there is …
Theoretical Biology, Evolutionary Oncology, Bioinformatics, or simply Basic Science, there is …
Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer
Glutamine can play a critical role in cellular growth in multiple cancers. Glutamine‐addicted
cancer cells are dependent on glutamine for viability, and their metabolism is reprogrammed …
cancer cells are dependent on glutamine for viability, and their metabolism is reprogrammed …
Mesoscale physical principles of collective cell organization
We review recent evidence showing that cell and tissue dynamics are governed by
mesoscale physical principles. These principles can be understood in terms of simple state …
mesoscale physical principles. These principles can be understood in terms of simple state …
Homeostatic membrane tension constrains cancer cell dissemination by counteracting BAR protein assembly
K Tsujita, R Satow, S Asada, Y Nakamura… - Nature …, 2021 - nature.com
Malignancy is associated with changes in cell mechanics that contribute to extensive cell
deformation required for metastatic dissemination. We hypothesized that the cell-intrinsic …
deformation required for metastatic dissemination. We hypothesized that the cell-intrinsic …
The mechanics of single cell and collective migration of tumor cells
Metastasis is a dynamic process in which cancer cells navigate the tumor microenvironment,
largely guided by external chemical and mechanical cues. Our current understanding of …
largely guided by external chemical and mechanical cues. Our current understanding of …
Can't handle the stress? Mechanobiology and disease
Mechanobiology is a rapidly growing research area focused on how mechanical forces and
properties influence biological systems at the cell, molecular, and tissue level, and how …
properties influence biological systems at the cell, molecular, and tissue level, and how …