Several hematopoietic cells of the immune system store large amounts of proteases in
cytoplasmic granules. The absolute majority of these proteases belong to the large family of …

Cells from several of the hematopoietic cell lineages including mast cells, basophils,
neutrophils, cytotoxic T cells, and natural killer (NK) cells store proteases at very high levels …

Thrombin is one of the most extensively studied of all proteases. Its central role in the
coagulation cascade as well as several other areas has been thoroughly documented …

In order for the intestinal mucosa to absorb dietary proteins they have to be digested into
single amino acids or very short peptides of a length of not more than four amino acids. In …

Serine proteases are major granule constituents of several of the human hematopoietic cell
lineages. Four proteolytically active such proteases have been identified in human …

Human neutrophils express at least four active serine proteases, cathepsin G, N-elastase,
proteinase 3 and neutrophil serine protease 4 (NSP4). They have all been extensively …

Mast cells of the rat intestinal mucosa express three chymotryptic enzymes named rMCP-2,-
3 and 4. rMCP-2, the most abundant of these enzymes, has been shown to increase the …

Thrombin is a serine protease of the chymotrypsin family that acts both as a procoagulant
and as an anticoagulant by cleaving either factor VIII, factor V and fibrinogen or protein C …

Serine proteases are the major protein constituents within mast cell secretory granules.
These proteases are subdivided into chymases and tryptases depending on their primary …

Granzyme B (GzmB) is primarily expressed by mammalian cytotoxic T cells and serves as
one of the key components in the defense against viral infection by the induction of …