Extensive scientific investigations in recent decades have established the anatomical,
biomechanical, and functional importance that the meniscus holds within the knee joint. As a …

There is substantial evidence that growth and remodeling of load bearing soft biological
tissues is to a large extent controlled by mechanical factors. Mechanical homeostasis, which …

Dupuytren disease, a clinical entity originally described more than 400 years ago, is a
progressive disease of genetic origin. Excessive myofibroblast proliferation and altered …

The spatiotemporal interaction and constant iterative feedback between fibroblasts,
extracellular matrix, and environmental cues are central for investigating the fibroblast …

Mechanical properties of healthy and Dupuytren fibroblasts were investigated by atomic
force microscopy (AFM). In addition to standard force curves, rheological properties were …

Dupuytren's disease (DD) is a progressive fibrosis of the palmar fascia characterized by the
formation of a nodule, which evolves into a cord. DD is the most common hereditary disease …

Tumor progression is mediated by reciprocal interaction between tumor cells and their
surrounding tumor microenvironment (TME), which among other factors encompasses the …

Background Dupuytren's disease is a fibroproliferative disorder of the palmar fascia. The
treatment used to date has mostly been surgery, but there is a high recurrence rate …

The Ehlers-Danlos syndromes (EDS) are a group of 13 disorders, clinically defined through
features of joint hypermobility, skin hyperextensibility, and tissue fragility. Most subtypes are …

Myofibroblasts provide a force to decrease the surface area of breast implant capsules as
the collagen matrix matures. 17-β-Oestradiol promotes myofibroblast differentiation and …