The scope, functions, and dynamics of posttranslational protein modifications

AH Millar, JL Heazlewood, C Giglione… - Annual review of …, 2019 - annualreviews.org
Assessing posttranslational modification (PTM) patterns within protein molecules and
reading their functional implications present grand challenges for plant biology. We combine …

Post-translational modifications of transporters

LC Czuba, KM Hillgren, PW Swaan - Pharmacology & therapeutics, 2018 - Elsevier
Drug transporter proteins are critical to the distribution of a wide range of endogenous
compounds and xenobiotics such as hormones, bile acids, peptides, lipids, sugars, and …

The role of solute carrier transporters in efficient anticancer drug delivery and therapy

E Puris, G Fricker, M Gynther - Pharmaceutics, 2023 - mdpi.com
Transporter-mediated drug resistance is a major obstacle in anticancer drug delivery and a
key reason for cancer drug therapy failure. Membrane solute carrier (SLC) transporters play …

Chemoproteomic profiling of O‐GlcNAcylated proteins and identification of O‐GlcNAc transferases in rice

X Li, C Lei, Q Song, L Bai, B Cheng… - Plant Biotechnology …, 2023 - Wiley Online Library
O‐linked β‐N‐acetylglucosaminylation (O‐GlcNAcylation) is a ubiquitous post‐translation
modification occurring in both animals and plants. Thousands of proteins along with their O …

Dissecting structure-encoded determinants of allosteric cross-talk between post-translational modification sites in the Hsp90 chaperones

G Stetz, A Tse, GM Verkhivker - Scientific reports, 2018 - nature.com
Post-translational modifications (PTMs) represent an important regulatory instrument that
modulates structure, dynamics and function of proteins. The large number of PTM sites in the …

Chromatin ubiquitination Guides DNA double strand break signaling and repair

KG Kolobynina, A Rapp, MC Cardoso - Frontiers in Cell and …, 2022 - frontiersin.org
Chromatin is the context for all DNA-based molecular processes taking place in the cell
nucleus. The initial chromatin structure at the site of the DNA damage determines both …

Exploring the diversity of plant proteome

Y Chen, Y Wang, J Yang, W Zhou… - Journal of Integrative …, 2021 - Wiley Online Library
The tremendous functional, spatial, and temporal diversity of the plant proteome is regulated
by multiple factors that continuously modify protein abundance, modifications, interactions …

Estimating the distribution of protein post-translational modification states by mass spectrometry

PD Compton, NL Kelleher… - Journal of proteome …, 2018 - ACS Publications
Post-translational modifications (PTMs) of proteins play a central role in cellular information
encoding, but the complexity of PTM state has been challenging to unravel. A single …

Co-occurring protein phosphorylation are functionally associated

Y Li, X Zhou, Z Zhai, T Li - PLoS computational biology, 2017 - journals.plos.org
Post-translational modifications (PTMs) add a further layer of complexity to the proteome and
regulate a wide range of cellular protein functions. With the increasing number of known …

Optical chemosensors for the detection of proximally phosphorylated peptides and proteins

AD Cabral, TB Radu, ED de Araujo… - RSC Chemical Biology, 2021 - pubs.rsc.org
Proximal multi-site phosphorylation is a critical post-translational modification in protein
biology. The additive effects of multiple phosphosite clusters in close spatial proximity …