The primary regulators of metazoan gene expression are enhancers, originally functionally
defined as DNA sequences that can activate transcription at promoters in an orientation …

Cell type-and differentiation-specific gene expression is precisely controlled by genomic non-
coding regulatory elements (NCREs), which include promoters, enhancers, silencers and …

The rise of large-scale, sequence-based deep neural networks (DNNs) for predicting gene
expression has introduced challenges in their evaluation and interpretation. Current …

Silencers are noncoding DNA sequence fragments located on the genome that suppress
gene expression. The variation of silencers in specific cells is closely related to gene …

Sequencing-based map** of ensemble pairwise interactions among regulatory elements
support the existence of topological assemblies known as promoter-enhancer hubs or …

The multi-level spatial chromatin organization in the nucleus is closely related to chromatin
activity. The mechanism of chromatin organization and remodeling attract much attention …

Silencers are repressive cis-regulatory elements that play crucial roles in transcriptional
regulation. Experimental methods for identifying silencers are always costly and time …

Enhancers not only activate target promoters to stimulate messenger RNA (mRNA)
synthesis, but they themselves also undergo transcription to produce enhancer RNAs …

Repressor elements significantly influence economically relevant phenotypes in pigs;
however, their precise roles and characteristics are inadequately understood. In the present …

Cis-regulatory elements (CRE) are critical for coordinating gene expression programs that
dictate cell-specific differentiation and homeostasis. Recently developed self-transcribing …