AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …

The clinical and commercial success of covalent drugs has prompted a renewed and more
deliberate pursuit of covalent and irreversible mechanisms within drug discovery. A covalent …

Peroxisome proliferator-activated receptor α is a potent regulator of systemic and cellular
metabolism and energy homeostasis, but it also suppresses various inflammatory reactions …

The presence and function of CB2 receptors in central nervous system (CNS) neurons are
controversial. We report the expression of CB2 receptor messenger RNA and protein …

Endocannabinoids and their attending cannabinoid type 1 (CB 1) receptor have been
implicated in animal models of post-traumatic stress disorder (PTSD). However, their specific …

Arachidonoylglycerol (2-AG) and anandamide are endocannabinoids that activate the
cannabinoid receptors CB1 and CB2. Endocannabinoid signaling is terminated by …

Endocannabinoids are lipid chemical mediators that act locally by activating cannabinoid
receptors of type 1 (CB 1) and type 2 (CB 2) receptors. The two most-studied …

Considerable evidence demonstrates that manipulation of the endocannabinoid system
regulates nausea and vomiting in humans and other animals. The anti‐emetic effect of …

Abstract The endocannabinoid 2-arachidonoylglycerol (2-AG) regulates neurotransmission
and neuroinflammation by activating CB1 cannabinoid receptors on neurons and CB2 …

This article presents several covalent inhibitors, including examples of successful drugs, as
well as highly selective, irreversible inhibitors of emerging therapeutic targets, such as fatty …