Complex genetic mechanisms in glaucoma: an overview

KN Rao, S Nagireddy… - Indian journal of …, 2011 - journals.lww.com
Glaucomas comprise a group of hereditary optic neuropathies characterized by progressive
and irreversible visual field loss and damage to the optic nerve head. It is a complex disease …

Complex genetics of complex traits: the case of primary open‐angle glaucoma

AW Hewitt, JE Craig, DA Mackey - Clinical & experimental …, 2006 - Wiley Online Library
Glaucoma, which is a complex heterogeneous disease, presents an ideal case for genetic
investigation. Primary open‐angle glaucoma (POAG) is the commonest subtype and will be …

Renin–angiotensin system involvement in the oxidative stress-induced neurodegeneration of cultured retinal ganglion cells

Y Ozawa, K Yuki, R Yamagishi, K Tsubota… - Japanese journal of …, 2013 - Springer
Purpose To analyze the influence of oxidative stress on retinal ganglion cells (RGCs) by
using a selective culture system of rat RGCs. Methods Rat RGCs were purified by a two-step …

Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma

JH Kang, SJ Loomis, BL Yaspan, JC Bailey… - Eye, 2014 - nature.com
Aims Vascular perfusion may be impaired in primary open-angle glaucoma (POAG); thus,
we evaluated a panel of markers in vascular tone-regulating genes in relation to POAG …

Association of angiotensin-converting enzyme, CYP46A1 genes polymorphism with senile cataract

ST Raza, S Abbas, A Chandra, L Singh… - Oman Journal of …, 2017 - journals.lww.com
Background: Senile cataract is the most common type of cataract characterized by gradual
progressive thickening of the lens of the eye. Previously, many studies investigated the …

Glaucomics: A Call for Systems Diagnostics for 21st Century Ophthalmology and Personalized Visual Health

K Güngör, PJ Hotez, V Özdemir… - Omics: a journal of …, 2014 - liebertpub.com
This article analyzes and theorizes the current knowledge silos at the intersection of omics
science, ophthalmology, personalized medicine, and global visual health. Visual disorders …

No relation between angiotensin-converting enzyme gene polymorphism and pseudoexfoliation

O Tekeli, ME Turaçlı, B Altınok, N Akar, AH Elhan - Ophthalmic research, 2007 - karger.com
Aims: To determine the association between the angiotensin-converting enzyme
insertion/deletion (I/D) polymorphism and pseudoexfoliation (PEX) in Turkish patients …

Association of GNB3, ACE polymorphisms with POAG and NTG

AN Samoylov, P Tumanova, SA Pankratova… - Ophthalmic …, 2024 - Taylor & Francis
Purpose Primary open-angle glaucoma (POAG) represents the most prevalent form of
glaucoma and stands as a foremost contributor to irreversible vision impairment on a global …

ACE and LRPAP1 insertion-deletion Polymorphisms in a northern Ivory Coast population

A Santovito, C Bulgarello, GA Caravatti, M Ouattará… - Human …, 2007 - muse.jhu.edu
The ACE and the LRPAP1 gene insertion-deletion polymorphisms were determined in 133
healthy individuals sampled from Ouangolodougou, a village located in northern Ivory …

[KİTAP][B] Molecular Genomics of Primary Open Angle Glaucoma

S Rong - 2014 - search.proquest.com
Glaucoma is a group of optic neuropathies characterized by optic disc excavation,
neuroretinal rim narrowing, retinal nerve fiber layer thinning, and progressive loss in visual …