The cells and tissues that make up our body manage contradictory mechanical demands. It
is crucial for their survival to be able to withstand large mechanical loads, but it is equally …

During embryogenesis, organisms acquire their shape given boundary conditions that
impose geometrical, mechanical and biochemical constraints. A detailed integrative …

Mechanical work serves as the foundation for dynamic cellular processes, ranging from cell
division to migration. A fundamental driver of cellular mechanical work is the actin …

Active stresses are generated and transmitted throughout diverse F-actin architectures
within the cell cytoskeleton, and drive essential behaviors of the cell, from cell division to …

During cell division, mitotic motors organize microtubules in the bipolar spindle into either
polar arrays at the spindle poles or a" nematic" network of aligned microtubules at the …

We study a reconstituted composite system consisting of an active microtubule network
interdigitated with a passive network of entangled F-actin filaments. Increasing the …

One of the major challenges of bottom-up synthetic biology is rebuilding a minimal cell
division machinery. From a reconstitution perspective, the animal cell division apparatus is …

For head and neck squamous cell carcinoma (HNSCC), the local invasion and distant
metastasis represent the predominant causes of mortality. Targeted inhibition of chemokines …

Cell-cell junctions, in particular adherens junctions, are major determinants of tissue
mechanics during morphogenesis and homeostasis. In attempts to link junctional mechanics …

Mechanical forces play a crucial role in diverse physiological processes, such as cell
migration, cytokinesis, and morphogenesis. The actin cytoskeleton generates a large …