Transcription factors (TFs) are key regulators of intrinsic cellular processes, such as
differentiation and development, and of the cellular response to external perturbation …

Enhancers are genomic sequences that play a key role in regulating tissue-specific gene
expression levels. An increasing number of diseases are linked to impaired enhancer …

Enhancers play a central role in the spatiotemporal control of gene expression and tend to
work in a cell-type-specific manner. In addition, they are suggested to be major contributors …

In recent years, major advances have been made in the understanding of the cellular and
molecular mechanisms driving pulmonary vascular remodelling in various forms of …

Serotonin acts solely via 5-HT4-receptors to control human cardiac contractile function. The
effects of serotonin via 5-HT4-receptors lead to positive inotropic and chronotropic effects, as …

Background: Metabolic alterations provide substrates that influence chromatin structure to
regulate gene expression that determines cell function in health and disease. Heightened …

Phenotypic alterations in resident vascular cells contribute to the vascular remodeling
process in diseases such as pulmonary (arterial) hypertension [P (A) H]. How the molecular …

Pulmonary hypertension is a complex disease with multiple causes, corresponding to
phenotypic heterogeneity and variable therapeutic responses. Advancing understanding of …

Epigenetic mechanisms represent potential molecular routes which could bridge the gap
between genetic background and environmental risk factors contributing to the …

Enhancers are deoxyribonucleic acid (DNA) fragments which when bound by transcription
factors enhance the transcription of related genes. Due to its sporadic distribution and …