Much of our knowledge on K+-channels was elucidated using specific peptide ligands
isolated from a number of venomous organisms. Recently, this field received a strong …

▪ Abstract Potassium (K+) channels are tetrameric membrane-spanning proteins that provide
a selective pore for the conductance of K+ across the cell membranes. These channels are …

Sequence-derived structural and physicochemical features have frequently been used in the
development of statistical learning models for predicting proteins and peptides of different …

K+ channels are macromolecules embedded in biological membranes, where they play a
key role in cellular excitability and signal transduction pathways. Knowledge of their …

Acid‐sensing ion channels (ASICs) are thought to be important ion channels, particularly for
the perception of pain. Some of them may also contribute to synaptic plasticity, learning, and …

Ion channels play critical roles in signaling processes and are attractive targets for treating
various diseases. Here we describe an NMR-based strategy for structural analyses of …

Insights into the interacting mode of CXCR4 with SDF-1α are crucial in understanding the
structural and functional characteristics of CXCR4 receptor. In this paper a computational …

Scorpion toxins are well-known as the largest potassium channel peptide blocker family.
They have been successfully proven to be valuable molecular probes for structural research …

Pi1 is a 35-residue scorpion toxin cross-linked by four disulphide bridges that acts potently
on both small-conductance Ca2+-activated (SK) and voltage-gated (Kv) K+ channel …

The discovery of new drugs that selectively block or modulate ion channels has great
potential to provide new treatments for a host of conditions. One promising avenue revolves …