Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …

Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …

Neurodegenerative disorders are characterized by the progressive dysfunction and death of
selectively vulnerable neuronal populations, often associated with the accumulation of …

The complement cascade is a critical effector mechanism of the innate immune system that
contributes to the rapid clearance of pathogens and dead or dying cells, as well as …

Activation of the innate immune system following pattern recognition receptor binding has
emerged as one of the major pathogenic mechanisms in neurodegenerative disease …

Inflammasomes are molecular scaffolds that are activated by damage-associated and
pathogen-associated molecular patterns and form a key element of innate immune …

The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …

There is a great clinical need to identify the underlying mechanisms, as well as related
biomarkers, and treatment targets, for traumatic brain injury (TBI). Neuroinflammation is a …