The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …

The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

The angiotensin II type 1 (AT1) receptor has a crucial role in load-induced cardiac
hypertrophy. Here we show that the AT1 receptor can be activated by mechanical stress …

The superfamily of G-protein-coupled receptors (GPCRs) could be subclassified into 7
families (A, B, large N-terminal family B-7 transmembrane helix, C, Frizzled/Smoothened …

Nearly 2000 G protein-coupled receptors (GPCRs) 1 have been reported since bovine opsin
was cloned in 1983 (1) and the-adrenergic receptor in 1986 (2). They are classified into over …

Abstract Angiotensin II (Ang II) activates a wide spectrum of signaling responses via the AT1
receptor (AT1R) that mediate its physiological control of blood pressure, thirst, and sodium …

Examples of G-protein-coupled receptors that can be biochemically detected in homo-or
heteromeric complexes are emerging at an accelerated rate. Biophysical approaches have …

The chemokine stromal cell‐derived factor (SDF‐1α), the ligand for the CXCR4 receptor,
induces a wide variety of effects that include calcium mobilization, chemotactic responses …

Mitogenic signaling by G-protein-coupled receptors (GPCRs) involves tyrosine
phosphorylation of adaptor proteins and assembly of multiprotein Ras activation complexes …

The importance of the renin angiotensin aldosterone system in cardiovascular physiology
and pathophysiology has been well described whereas the detailed molecular mechanisms …