Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

Psychosis is a heterogeneous psychiatric condition for which a multitude of risk and
protective factors have been suggested. This umbrella review aimed to classify the strength …

Preventive approaches have latterly gained traction for improving mental health in young
people. In this paper, we first appraise the conceptual foundations of preventive psychiatry …

Importance Detection, prognosis, and indicated interventions in individuals at clinical high
risk for psychosis (CHR-P) are key components of preventive psychiatry. Objective To …

Objectives: This guideline provides recommendations for the clinical management of
schizophrenia and related disorders for health professionals working in Australia and New …

Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibility to
diseases, calculated for individuals as weighted counts of thousands of risk variants in which …

Promotion of good mental health in young people with and without mental disorders has
received little empirical research attention and interventions for improving mental health in …

Outcomes of psychotic disorders are associated with high personal, familiar, societal and
clinical burden. There is thus an urgent clinical and societal need for improving those …

We report the current best estimate of the effects of cognitive behavior therapy (CBT) in the
treatment of major depression (MDD), generalized anxiety disorder (GAD), panic disorder …

Objective: Approximately 20%–35% of individuals 12–35 years old who meet criteria for a
prodromal risk syndrome convert to psychosis within 2 years. However, this estimate ignores …