[HTML][HTML] Corneal structure and transparency

KM Meek, C Knupp - Progress in retinal and eye research, 2015 - Elsevier
The corneal stroma plays several pivotal roles within the eye. Optically, it is the main
refracting lens and thus has to combine almost perfect transmission of visible light with …

Corneal stromal repair and regeneration

RR Mohan, D Kempuraj, S D'Souza, A Ghosh - Progress in retinal and eye …, 2022 - Elsevier
The cornea is a specialized, transparent, avascular, immune-privileged, and heavily
innervated tissue that affords 2/3rd of refraction to the eye. Ocular injuries, infections, and …

In vitro mineralization of collagen

BM Oosterlaken, MP Vena, G de With - Advanced Materials, 2021 - Wiley Online Library
Collagen mineralization is a biological process in many skeletal elements in the animal
kingdom. Examples of these collagen‐based skeletons are the siliceous spicules of glass …

Bioengineered corneal tissue for minimally invasive vision restoration in advanced keratoconus in two clinical cohorts

M Rafat, M Jabbarvand, N Sharma, M Xeroudaki… - Nature …, 2023 - nature.com
Visual impairment from corneal stromal disease affects millions worldwide. We describe a
cell-free engineered corneal tissue, bioengineered porcine construct, double crosslinked …

Light‐activated decellularized extracellular matrix‐based bioinks for volumetric tissue analogs at the centimeter scale

H Kim, B Kang, X Cui, SH Lee, K Lee… - Advanced Functional …, 2021 - Wiley Online Library
Tissue engineering requires not only tissue‐specific functionality but also a realistic scale.
Decellularized extracellular matrix (dECM) is presently applied to the extrusion‐based 3D …

Composition, structure and function of the corneal stroma

EM Espana, DE Birk - Experimental eye research, 2020 - Elsevier
No other tissue in the body depends more on the composition and organization of the
extracellular matrix (ECM) for normal structure and function than the corneal stroma. The …

[HTML][HTML] Dual-crosslinked regenerative hydrogel for sutureless long-term repair of corneal defect

X Shen, S Li, X Zhao, J Han, J Chen, Z Rao, K Zhang… - Bioactive Materials, 2023 - Elsevier
Corneal transplantation is the most effective clinical treatment for corneal defects, but it
requires precise size of donor corneas, surgical sutures, and overcoming other technical …

Guiding lights: tissue bioprinting using photoactivated materials

M Lee, R Rizzo, F Surman, M Zenobi-Wong - Chemical Reviews, 2020 - ACS Publications
Photoactivated materials have found widespread use in biological and medical applications
and are playing an increasingly important role in the nascent field of three-dimensional (3D) …

Designing scaffolds for corneal regeneration

M Ahearne, J Fernández‐Pérez… - Advanced Functional …, 2020 - Wiley Online Library
Corneal blindness is one of the most common causes of vision loss worldwide, affecting
millions of people. To treat these patients, researchers have been examining different …

Keratoconus

RB Singh, S Koh, N Sharma, FA Woreta… - Nature Reviews …, 2024 - nature.com
Keratoconus is a progressive eye disorder primarily affecting individuals in adolescence and
early adulthood. The ectatic changes in the cornea cause thinning and cone-like steepening …