Induced pluripotent stem cells and their use in human models of disease and development
The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …
Efficient generation and correction of mutations in human iPS cells utilizing mRNAs of CRISPR base editors and prime editors
D Sürün, A Schneider, J Mircetic, K Neumann… - Genes, 2020 - mdpi.com
In contrast to CRISPR/Cas9 nucleases, CRISPR base editors (BE) and prime editors (PE)
enable predefined nucleotide exchanges in genomic sequences without generating DNA …
enable predefined nucleotide exchanges in genomic sequences without generating DNA …