Motivational and motor deficits are common in patients with depression and other psychiatric
disorders, and are related to symptoms of anhedonia and motor retardation. These deficits in …

Most psychiatric disorders do not occur in isolation, and most psychiatric symptom
dimensions are not uniquely expressed within a single diagnostic category. Current …

Objective: Determine whether a novel psychosocial treatment for positive affect improves
clinical status and reward sensitivity more than a form of cognitive behavioral therapy that …

Objective: Loss of pleasure or interest in activities (ie, anhedonia) is a risk factor for
suicidality, treatment nonresponse, and relapse. Extant treatments that focus on reducing …

With the proliferation of multi-site neuroimaging studies, there is a greater need for handling
non-biological variance introduced by differences in MRI scanners and acquisition …

Acquiring resting‐state functional magnetic resonance imaging (fMRI) datasets at multiple
MRI scanners and clinical sites can improve statistical power and generalizability of results …

Anhedonia is one of the core symptoms of major depressive disorder (MDD), which is often
inadequately treated by traditional antidepressants. The modern framework of anhedonia …

Pleasure and motivation are important factors for goal-directed behavior and well-being in
both animals and humans. Intact hedonic capacity requires an undisturbed interplay …

Importance Major depressive disorder is prevalent and impairing. Parsing
neurocomputational substrates of reinforcement learning in individuals with depression may …

Anhedonia is a key symptom of major depressive disorder (MDD) and comprises
behavioural deficits in three reward processing subtypes: reward liking, reward wanting, and …