Inflammatory markers in Alzheimer's disease and mild cognitive impairment: a meta-analysis and systematic review of 170 studies

XN Shen, LD Niu, YJ Wang, XP Cao, Q Liu… - Journal of Neurology …, 2019 - jnnp.bmj.com
Objective Inflammation plays a crucial role in the pathogenesis of mild cognitive impairment
(MCI) and Alzheimer's disease (AD). Our study aimed to analyse previous inconsistent …

A walk through tau therapeutic strategies

S Jadhav, J Avila, M Schöll, GG Kovacs… - Acta neuropathologica …, 2019 - Springer
Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease
and related human tauopathies. There is a growing body of evidence indicating that …

A parameter-efficient deep learning approach to predict conversion from mild cognitive impairment to Alzheimer's disease

S Spasov, L Passamonti, A Duggento, P Lio, N Toschi… - Neuroimage, 2019 - Elsevier
Some forms of mild cognitive impairment (MCI) are the clinical precursors of Alzheimer's
disease (AD), while other MCI types tend to remain stable over-time and do not progress to …

A CNN based framework for classification of Alzheimer's disease

Y AbdulAzeem, WM Bahgat, M Badawy - Neural Computing and …, 2021 - Springer
In the current decade, advances in health care are attracting widespread interest due to their
contributions to people longer surviving and fitter lives. Alzheimer's disease (AD) is the …

[HTML][HTML] The diagnostic performance of neurofilament light chain in CSF and blood for Alzheimer's disease, frontotemporal dementia, and amyotrophic lateral sclerosis …

LM Forgrave, M Ma, JR Best, ML DeMarco - Alzheimer's & Dementia …, 2019 - Elsevier
Introduction A systematic review and meta-analysis was performed regarding the diagnostic
performance of neurofilament light chain (NfL) in CSF and blood. Methods A database …

Detection of aggregation-competent tau in neuron-derived extracellular vesicles

FX Guix, GT Corbett, DJ Cha, M Mustapic… - International journal of …, 2018 - mdpi.com
Progressive cerebral accumulation of tau aggregates is a defining feature of Alzheimer's
disease (AD). A popular theory that seeks to explain the apparent spread of neurofibrillary …

Potential role of chitinase‐3‐like protein 1 (CHI3L1/YKL‐40) in neurodegeneration and Alzheimer's disease

K Connolly, M Lehoux, R O'Rourke… - Alzheimer's & …, 2023 - Wiley Online Library
Abstract Chitinase‐3‐like protein 1 (CHI3L1/YKL‐40) has long been known as a biomarker
for early detection of neuroinflammation and disease diagnosis of Alzheimer's disease (AD) …

Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease

A Vergallo, L Mégret, S Lista, E Cavedo… - Alzheimer's & …, 2019 - Elsevier
Introduction Blood-based biomarkers of pathophysiological brain amyloid β (Aβ)
accumulation, particularly for preclinical target and large-scale interventions, are warranted …

[HTML][HTML] Genetic architecture of Alzheimer's disease

SM Neuner, TCW Julia, AM Goate - Neurobiology of disease, 2020 - Elsevier
Advances in genetic and genomic technologies over the last thirty years have greatly
enhanced our knowledge concerning the genetic architecture of Alzheimer's disease (AD) …

The potential of blood neurofilament light as a marker of neurodegeneration for Alzheimer's disease

Y Jung, JS Damoiseaux - Brain, 2024 - academic.oup.com
Over the past several years, there has been a surge in blood biomarker studies examining
the value of plasma or serum neurofilament light (NfL) as a biomarker of neurodegeneration …