The yeast Saccharomyces cerevisiae has been a favorite organism for pioneering studies
on nutrient-sensing and signaling mechanisms. Many specific nutrient responses have been …

Yeast cells sense the amount and quality of external nutrients through multiple
interconnected signaling networks, which allow them to adjust their metabolism …

Cells of all living organisms contain complex signal transduction networks to ensure that a
wide range of physiological properties are properly adapted to the environmental conditions …

The TOR (target of rapamycin), an atypical protein kinase, is evolutionarily conserved from
yeast to man. Pharmacological studies using rapamycin to inhibit TOR and yeast genetic …

While fungi are widely occupying nature, many species are responsible for devastating
mycosis in humans. Such niche diversity explains how quick fungal adaptation is necessary …

Autophagy is a conserved catabolic process that initially involves the bulk or the selective
engulfment of cytosolic components into double-membrane vesicles and successively the …

The ability to sense and adapt to a hostile host environment is a crucial element for virulence
of pathogenic fungi, including Cryptococcus neoformans. These cellular responses are …

The ability of fungal pathogens to survive hostile environments within the host depends on
rapid and robust stress responses. Stress-activated protein kinase (SAPK) pathways are …

Maf1 is a conserved repressor of transcription that functions at the downstream end of
multiple nutrient and stress signaling pathways. How these different signaling pathways …

The Target of Rapamycin (TOR), a protein kinase, is the central node of a highly conserved
signaling network that regulates cell growth in response to nutrients, hormones, and …