The most fundamental feature of cellular form is size, which sets the scale of all cell
biological processes. Growth, form, and function are all necessarily linked in cell biology, but …

BACKGROUND How do the different cell types in our bodies maintain their distinctive and
characteristic sizes? Although much is known about the signaling networks that stimulate or …

Live-cell imaging has opened an exciting window into the role cellular heterogeneity plays
in dynamic, living systems. A major critical challenge for this class of experiments is the …

Evolutionarily divergent bacteria share a common phenomenological strategy for cell-size
homeostasis under steady-state conditions. In the presence of inherent physiological …

Isogenic E. coli cells growing in a constant environment display significant variability in
growth rates, division sizes, and generation times. The guiding principle appears to be that …

Predictive biology is the next great chapter in synthetic and systems biology, particularly for
microorganisms. Tasks that once seemed infeasible are increasingly being realized such as …

How the coexistence of many species is maintained is a fundamental and unresolved
question in ecology. Coexistence is a puzzle because we lack a mechanistic understanding …

One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

Despite decades of research, how mammalian cell size is controlled remains unclear
because of the difficulty of directly measuring growth at the single-cell level. Here we report …

It is generally assumed that the allocation and synthesis of total cellular resources in
microorganisms are uniquely determined by the growth conditions. Adaptation to a new …